Pharmacology of the colony-stimulating factors

George Morstyn, Graham J. Lieschke, William Sheridan, Judith Layton, Jonathan Cebon

Research output: Contribution to journalReview ArticleResearchpeer-review

38 Citations (Scopus)

Abstract

Leukocyte production is influenced by a family of glycoproteins called colony-stimulating factors. Two of these have been purified, cloned and produced in quantities sufficient for clinical use. Granulocyte colony-stimulating factor (G-CSF) preferentially stimulates neutrophil production and has been shoivn to reduce the duration of neutropenia folloiving chemotherapy. G-CSF therapy also has beneficial effects in a variety of other neutropenic states. Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates neutrophil, monocyte and eosinophil production and function. GM-CSF is associated with more diverse haematological and clinical effects. George Morstyn and colleagues summarize the promising results from the early clinical trials with these new therapeutic agents.

Original languageEnglish
Pages (from-to)154-159
Number of pages6
JournalTrends in Pharmacological Sciences
Volume10
Issue number4
DOIs
Publication statusPublished - 1989
Externally publishedYes

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