Pharmacology of celiprolol

W. J. Louis, O. H. Drummer, L. H. Tung

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Abstract

The pharmacology of celiprolol and its relationship to some other beta-adrenoceptor antagonists is described. Celiprolol is a potent beta blocker on beta1-adrenoceptors and exhibits cardioselectivity both in vitro [5,7] and in vivo in the pithed rat, but shows no significant invitro alpha1-blocking action. Celiprolol differs from atenolol in that it has an intrinsic sympathomimetic activity (ISA) for beta1-adrenoceptors, which is reflected in its relative lack of negative inotropic effects in humans. In the pithed rat, celiprolol's ISA was demonstrated at much lower doses than for pindolol, even though pindolol has a similar potency to celiprolol in antagonizing the heart rate effects of isoproterenol. It was completely blocked by propranolol, indicating that celiprolol behaves like a partial agonist for beta1-adrenoceptors, whereas the ISA developed by pindolol was only partially blocked by propranolol. These data suggest a different mechanism for he development of ISA between celiprolol and pindolol.

Original languageEnglish
Pages (from-to)1281-1286
Number of pages5
JournalCardiovascular Drugs and Therapy
Volume4
Issue number6 Supplement
DOIs
Publication statusPublished - 1990
Externally publishedYes

Keywords

  • cardioselectivity
  • celiprolol
  • intrinsic sympathomimetic activity
  • pindolol
  • propranolol

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