Pharmacological effects of grifolin: Focusing on anticancer mechanisms

Abdelhakim Bouyahya, Aicha El Allam, Ikrame Zeouk, Douae Taha, Gokhan Zengin, Bey Hing Goh, Michelina Catauro, Domenico Montesano, Nasreddine El Omari

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Grifolin is a volatile compound contained in essential oils of several medicinal plants. Several studies show that this substance has been the subject of numerous pharmacological investiga-tions, which have yielded interesting results. Grifolin demonstrated beneficial effects for health via its multiple pharmacological activities. It has anti-microbial properties against bacteria, fungi, and parasites. In addition, grifolin exhibited remarkable anti-cancer effects on different human cancer cells. The anticancer action of this molecule is related to its ability to act at cellular and molecular levels on different checkpoints controlling the signaling pathways of human cancer cell lines. Gri-folin can induce apoptosis, cell cycle arrest, autophagy, and senescence in these cells. Despite its major pharmacological properties, grifolin has only been investigated in vitro and in vivo. Therefore, further investigations concerning pharmacodynamic and pharmacokinetic tests are required for any possible pharmaceutical application of this substance. Moreover, toxicological tests and other investigations involving humans as a study model are required to validate the safety and clinical applications of grifolin.

Original languageEnglish
Article number284
Number of pages14
JournalMolecules
Volume27
Issue number1
DOIs
Publication statusPublished - 1 Jan 2022

Keywords

  • Anticancer effect
  • Apoptosis
  • Grifolin
  • NF-κB
  • Pharmacodynamic

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