TY - JOUR
T1 - Pharmacological effects of grifolin
T2 - Focusing on anticancer mechanisms
AU - Bouyahya, Abdelhakim
AU - Allam, Aicha El
AU - Zeouk, Ikrame
AU - Taha, Douae
AU - Zengin, Gokhan
AU - Goh, Bey Hing
AU - Catauro, Michelina
AU - Montesano, Domenico
AU - Omari, Nasreddine El
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Grifolin is a volatile compound contained in essential oils of several medicinal plants. Several studies show that this substance has been the subject of numerous pharmacological investiga-tions, which have yielded interesting results. Grifolin demonstrated beneficial effects for health via its multiple pharmacological activities. It has anti-microbial properties against bacteria, fungi, and parasites. In addition, grifolin exhibited remarkable anti-cancer effects on different human cancer cells. The anticancer action of this molecule is related to its ability to act at cellular and molecular levels on different checkpoints controlling the signaling pathways of human cancer cell lines. Gri-folin can induce apoptosis, cell cycle arrest, autophagy, and senescence in these cells. Despite its major pharmacological properties, grifolin has only been investigated in vitro and in vivo. Therefore, further investigations concerning pharmacodynamic and pharmacokinetic tests are required for any possible pharmaceutical application of this substance. Moreover, toxicological tests and other investigations involving humans as a study model are required to validate the safety and clinical applications of grifolin.
AB - Grifolin is a volatile compound contained in essential oils of several medicinal plants. Several studies show that this substance has been the subject of numerous pharmacological investiga-tions, which have yielded interesting results. Grifolin demonstrated beneficial effects for health via its multiple pharmacological activities. It has anti-microbial properties against bacteria, fungi, and parasites. In addition, grifolin exhibited remarkable anti-cancer effects on different human cancer cells. The anticancer action of this molecule is related to its ability to act at cellular and molecular levels on different checkpoints controlling the signaling pathways of human cancer cell lines. Gri-folin can induce apoptosis, cell cycle arrest, autophagy, and senescence in these cells. Despite its major pharmacological properties, grifolin has only been investigated in vitro and in vivo. Therefore, further investigations concerning pharmacodynamic and pharmacokinetic tests are required for any possible pharmaceutical application of this substance. Moreover, toxicological tests and other investigations involving humans as a study model are required to validate the safety and clinical applications of grifolin.
KW - Anticancer effect
KW - Apoptosis
KW - Grifolin
KW - NF-κB
KW - Pharmacodynamic
UR - http://www.scopus.com/inward/record.url?scp=85122148958&partnerID=8YFLogxK
U2 - 10.3390/molecules27010284
DO - 10.3390/molecules27010284
M3 - Review Article
C2 - 35011516
AN - SCOPUS:85122148958
VL - 27
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 1
M1 - 284
ER -