Pharmacological and Nonpharmacological Interventions for Cognitive Impairment and Dementia Related to Type 2 Diabetes and Metabolic Disturbances in Aging

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Few pharmacological interventions are available for the management of dementia in general, and to date none modify the underlying disease process. Similarly, no treatments are currently available that target cognitive impairment in individuals with type 2 diabetes mellitus (T2D). However, there have been a number of clinical trials and observational studies that can guide potential future avenues of investigation. Blood pressure-lowering and certain glucose-lowering drugs may have some therapeutic benefit in reducing the risk for cognitive impairment but conclusive evidence is lacking. Nonpharmacological interventions such as diet and exercise also show potential benefits. Because of the potentially large number of mechanisms through which T2D contributes to cognitive impairment, multimodal interventions targeting many pathways simultaneously may hold the most promise.

Original languageEnglish
Title of host publicationType 2 Diabetes and Dementia
EditorsVelandai Srikanth, Zoe Arvanitakis
Place of PublicationUnited Kingdom
PublisherAcademic Press
Number of pages23
ISBN (Electronic)9780128096949
ISBN (Print)9780128094549
Publication statusPublished - 6 Mar 2018


  • Cognition
  • Dementia
  • Nonpharmacological
  • Pharmacological
  • Type 2 diabetes

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