Few pharmacological interventions are available for the management of dementia in general, and to date none modify the underlying disease process. Similarly, no treatments are currently available that target cognitive impairment in individuals with type 2 diabetes mellitus (T2D). However, there have been a number of clinical trials and observational studies that can guide potential future avenues of investigation. Blood pressure-lowering and certain glucose-lowering drugs may have some therapeutic benefit in reducing the risk for cognitive impairment but conclusive evidence is lacking. Nonpharmacological interventions such as diet and exercise also show potential benefits. Because of the potentially large number of mechanisms through which T2D contributes to cognitive impairment, multimodal interventions targeting many pathways simultaneously may hold the most promise.
|Title of host publication||Type 2 Diabetes and Dementia|
|Editors||Velandai Srikanth, Zoe Arvanitakis|
|Place of Publication||United Kingdom|
|Number of pages||23|
|Publication status||Published - 6 Mar 2018|
- Type 2 diabetes