Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically Ill patients

Alan Forrest; Samira M. Garonzik; Visanu Thamlikitkul; Evangelos J. Giamarellos-Bourboulis; David L. Paterson; Jian Li; Fernanda P. Silveira; Roger L. Nation

doi:10.1128/AAC.01367-17

Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically Ill patients

Alan Forrest, Samira M. Garonzik, Visanu Thamlikitkul, Evangelos J. Giamarellos-Bourboulis, David L. Paterson, Jian Li, Fernanda P. Silveira, Roger L. Nation

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically ill patients, none of whom were receiving renal replacement therapy. Tree-based modeling revealed that the rates of AKI were substantially higher when the average steady-state plasma colistin concentration was greater than ∼2 mg/liter.

Original language	English
Article number	e01367
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	11
DOIs	https://doi.org/10.1128/AAC.01367-17
Publication status	Published - 1 Nov 2017

Keywords

Acute kidney injury
Colistin
PK/TD relationship

Access to Document

10.1128/AAC.01367-17

235415150-oaFinal published version, 574 KB

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Cite this

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title = "Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically Ill patients",

abstract = "Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically ill patients, none of whom were receiving renal replacement therapy. Tree-based modeling revealed that the rates of AKI were substantially higher when the average steady-state plasma colistin concentration was greater than ∼2 mg/liter.",

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Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically Ill patients. / Forrest, Alan; Garonzik, Samira M.; Thamlikitkul, Visanu; Giamarellos-Bourboulis, Evangelos J.; Paterson, David L.; Li, Jian; Silveira, Fernanda P.; Nation, Roger L.

In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 11, e01367, 01.11.2017.

Research output: Contribution to journal › Article › Research › peer-review

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