Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically Ill patients

Alan Forrest, Samira M. Garonzik, Visanu Thamlikitkul, Evangelos J. Giamarellos-Bourboulis, David L. Paterson, Jian Li, Fernanda P. Silveira, Roger L. Nation

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Abstract

Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically ill patients, none of whom were receiving renal replacement therapy. Tree-based modeling revealed that the rates of AKI were substantially higher when the average steady-state plasma colistin concentration was greater than ∼2 mg/liter.

Original languageEnglish
Article numbere01367
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • Acute kidney injury
  • Colistin
  • PK/TD relationship

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