Abstract
Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically ill patients, none of whom were receiving renal replacement therapy. Tree-based modeling revealed that the rates of AKI were substantially higher when the average steady-state plasma colistin concentration was greater than ∼2 mg/liter.
Original language | English |
---|---|
Article number | e01367 |
Number of pages | 5 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 61 |
Issue number | 11 |
DOIs | |
Publication status | Published - 1 Nov 2017 |
Keywords
- Acute kidney injury
- Colistin
- PK/TD relationship