Abstract
Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically ill patients, none of whom were receiving renal replacement therapy. Tree-based modeling revealed that the rates of AKI were substantially higher when the average steady-state plasma colistin concentration was greater than ∼2 mg/liter.
| Original language | English |
|---|---|
| Article number | e01367 |
| Number of pages | 5 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 61 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1 Nov 2017 |
Keywords
- Acute kidney injury
- Colistin
- PK/TD relationship
Cite this
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Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically Ill patients. / Forrest, Alan; Garonzik, Samira M.; Thamlikitkul, Visanu; Giamarellos-Bourboulis, Evangelos J.; Paterson, David L.; Li, Jian; Silveira, Fernanda P.; Nation, Roger L.
In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 11, e01367, 01.11.2017.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically Ill patients
AU - Forrest, Alan
AU - Garonzik, Samira M.
AU - Thamlikitkul, Visanu
AU - Giamarellos-Bourboulis, Evangelos J.
AU - Paterson, David L.
AU - Li, Jian
AU - Silveira, Fernanda P.
AU - Nation, Roger L.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically ill patients, none of whom were receiving renal replacement therapy. Tree-based modeling revealed that the rates of AKI were substantially higher when the average steady-state plasma colistin concentration was greater than ∼2 mg/liter.
AB - Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically ill patients, none of whom were receiving renal replacement therapy. Tree-based modeling revealed that the rates of AKI were substantially higher when the average steady-state plasma colistin concentration was greater than ∼2 mg/liter.
KW - Acute kidney injury
KW - Colistin
KW - PK/TD relationship
UR - http://www.scopus.com/inward/record.url?scp=85032507103&partnerID=8YFLogxK
U2 - 10.1128/AAC.01367-17
DO - 10.1128/AAC.01367-17
M3 - Article
VL - 61
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 1098-6596
IS - 11
M1 - e01367
ER -