Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically Ill patients

Alan Forrest, Samira M. Garonzik, Visanu Thamlikitkul, Evangelos J. Giamarellos-Bourboulis, David L. Paterson, Jian Li, Fernanda P. Silveira, Roger L. Nation

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Acute kidney injury (AKI) occurs in a substantial proportion of critically ill patients receiving intravenous colistin. In the pharmacokinetic/toxicodynamic analysis reported here, the relationship of the occurrence of AKI to exposure to colistin and a number of potential patient factors was explored in 153 critically ill patients, none of whom were receiving renal replacement therapy. Tree-based modeling revealed that the rates of AKI were substantially higher when the average steady-state plasma colistin concentration was greater than ∼2 mg/liter.

Original languageEnglish
Article numbere01367
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • Acute kidney injury
  • Colistin
  • PK/TD relationship

Cite this

Forrest, Alan ; Garonzik, Samira M. ; Thamlikitkul, Visanu ; Giamarellos-Bourboulis, Evangelos J. ; Paterson, David L. ; Li, Jian ; Silveira, Fernanda P. ; Nation, Roger L. / Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically Ill patients. In: Antimicrobial Agents and Chemotherapy. 2017 ; Vol. 61, No. 11.
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Forrest, A, Garonzik, SM, Thamlikitkul, V, Giamarellos-Bourboulis, EJ, Paterson, DL, Li, J, Silveira, FP & Nation, RL 2017, 'Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically Ill patients', Antimicrobial Agents and Chemotherapy, vol. 61, no. 11, e01367. https://doi.org/10.1128/AAC.01367-17

Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically Ill patients. / Forrest, Alan; Garonzik, Samira M.; Thamlikitkul, Visanu; Giamarellos-Bourboulis, Evangelos J.; Paterson, David L.; Li, Jian; Silveira, Fernanda P.; Nation, Roger L.

In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 11, e01367, 01.11.2017.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Forrest, Alan

AU - Garonzik, Samira M.

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AU - Paterson, David L.

AU - Li, Jian

AU - Silveira, Fernanda P.

AU - Nation, Roger L.

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