Objective: To test whether a prolonged 3-hour infusion of meropenem 500mg achieves an equivalent proportion of time above the minimal inhibitory concentration (MIC) ( TMIC) to that of meropenem 1000mg given over 30 minutes. Design, setting and participants: A randomised crossover study in 10 critically ill patients. Method: We administered meropenem as a 1000mg, 30-minute infusion or as a 500mg, 3-hour infusion. We determined serial plasma concentrations for each dosing episode and performed comparisons of TMIC at different MICs. Outcome measures: The percentage of time that meropenem was above its MIC. Results: For low MICs (=2 mg/L), both regimens attained a TMIC >40 in all patients. For an MIC of 4mg/L, this target was attained in all but one patient, but with an MIC of 8mg/L, three patients in each group had a TMIC
|Pages (from-to)||190 - 196|
|Number of pages||7|
|Journal||Critical Care and Resuscitation|
|Publication status||Published - 2014|
Langan, K., Jacob, J., Li, J., Nation, R. L., Bellomo, R., Howden, B. P., & Johnson, P. D. R. (2014). Pharmacokinetics of short versus extended infusion meropenem dosing in critically ill patients: A pilot study. Critical Care and Resuscitation, 16(3), 190 - 196.