TY - JOUR
T1 - Pharmacokinetics of short versus extended infusion meropenem dosing in critically ill patients: A pilot study
AU - Langan, Katherine
AU - Jacob, Jovan
AU - Li, Jian
AU - Nation, Roger Leigh
AU - Bellomo, Rinaldo
AU - Howden, Benjamin Peter
AU - Johnson, Paul Donald Russell
PY - 2014
Y1 - 2014
N2 - Objective: To test whether a prolonged 3-hour infusion of meropenem 500mg achieves an equivalent proportion of time above the minimal inhibitory concentration (MIC) ( TMIC) to that of meropenem 1000mg given over 30 minutes. Design, setting and participants: A randomised crossover study in 10 critically ill patients. Method: We administered meropenem as a 1000mg, 30-minute infusion or as a 500mg, 3-hour infusion. We determined serial plasma concentrations for each dosing episode and performed comparisons of TMIC at different MICs. Outcome measures: The percentage of time that meropenem was above its MIC. Results: For low MICs (=2 mg/L), both regimens attained a TMIC >40 in all patients. For an MIC of 4mg/L, this target was attained in all but one patient, but with an MIC of 8mg/L, three patients in each group had a TMIC
AB - Objective: To test whether a prolonged 3-hour infusion of meropenem 500mg achieves an equivalent proportion of time above the minimal inhibitory concentration (MIC) ( TMIC) to that of meropenem 1000mg given over 30 minutes. Design, setting and participants: A randomised crossover study in 10 critically ill patients. Method: We administered meropenem as a 1000mg, 30-minute infusion or as a 500mg, 3-hour infusion. We determined serial plasma concentrations for each dosing episode and performed comparisons of TMIC at different MICs. Outcome measures: The percentage of time that meropenem was above its MIC. Results: For low MICs (=2 mg/L), both regimens attained a TMIC >40 in all patients. For an MIC of 4mg/L, this target was attained in all but one patient, but with an MIC of 8mg/L, three patients in each group had a TMIC
UR - http://search.informit.com.au.ezproxy.lib.monash.edu.au/fullText;dn=560806352563911;res=IELHEA
M3 - Article
VL - 16
SP - 190
EP - 196
JO - Critical Care and Resuscitation
JF - Critical Care and Resuscitation
SN - 1441-2772
IS - 3
ER -