Pharmacokinetics of gentamicin in very low birth weight preterm infants

K. W. Hindmarsh, R. L. Nation, G. L. Williams, E. John, J. N. French

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Low birth weight preterm infants with suspected infection were administered gentamicin intramuscularly every 18 h (2.5 mg/kg) or 24 h (3.0 mg/kg). For both dosage regimens plasma gentamicin levels were monitored during a dosage interval on three separate occasions over a 10 day period. Both regimens gave satisfactory plasma concentrations and there was no important statistically significant difference between the two. The body clearance of gentamicin correlated with gestational age (r=0.76, p<0.01). The results indicate either regimen may be useful in the clinical situation but from a practical standpoint administration every 24 h may be easier to comply with then every 18 h.

Original languageEnglish
Pages (from-to)649-653
Number of pages5
JournalEuropean Journal of Clinical Pharmacology
Volume24
Issue number5
DOIs
Publication statusPublished - 1 Sep 1983

Keywords

  • dosage regimens
  • gentamicin
  • low birth weight
  • pharmacokinetics
  • preterm infants

Cite this

Hindmarsh, K. W. ; Nation, R. L. ; Williams, G. L. ; John, E. ; French, J. N. / Pharmacokinetics of gentamicin in very low birth weight preterm infants. In: European Journal of Clinical Pharmacology. 1983 ; Vol. 24, No. 5. pp. 649-653.
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Pharmacokinetics of gentamicin in very low birth weight preterm infants. / Hindmarsh, K. W.; Nation, R. L.; Williams, G. L.; John, E.; French, J. N.

In: European Journal of Clinical Pharmacology, Vol. 24, No. 5, 01.09.1983, p. 649-653.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Nation, R. L.

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AU - John, E.

AU - French, J. N.

PY - 1983/9/1

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