Pharmacokinetics of gentamicin in very low birth weight preterm infants

K. W. Hindmarsh, R. L. Nation, G. L. Williams, E. John, J. N. French

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Abstract

Low birth weight preterm infants with suspected infection were administered gentamicin intramuscularly every 18 h (2.5 mg/kg) or 24 h (3.0 mg/kg). For both dosage regimens plasma gentamicin levels were monitored during a dosage interval on three separate occasions over a 10 day period. Both regimens gave satisfactory plasma concentrations and there was no important statistically significant difference between the two. The body clearance of gentamicin correlated with gestational age (r=0.76, p<0.01). The results indicate either regimen may be useful in the clinical situation but from a practical standpoint administration every 24 h may be easier to comply with then every 18 h.

Original languageEnglish
Pages (from-to)649-653
Number of pages5
JournalEuropean Journal of Clinical Pharmacology
Volume24
Issue number5
DOIs
Publication statusPublished - 1 Sep 1983

Keywords

  • dosage regimens
  • gentamicin
  • low birth weight
  • pharmacokinetics
  • preterm infants

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