Pharmacokinetics in the aged: A review

Edward J. Triggs, Roger L. Nation

Research output: Contribution to journalReview ArticleResearchpeer-review

125 Citations (Scopus)

Abstract

Age-related differences in drug response have recently received increased attention in the medical literature. This report reviews those recent publications dealing with the study of pharmacokinetics in the aged population. The rate and extent of drug absorption do not appear to be altered to any appreciable degree in the elderly patient. However, drug disposition in the aged subject may be affected by a number of factors including alterations in protein binding, apparent volumes of distribution, and renal and/or extrarenal clearance of the drug.

Original languageEnglish
Pages (from-to)387-418
Number of pages32
JournalJournal of Pharmacokinetics and Biopharmaceutics
Volume3
Issue number6
DOIs
Publication statusPublished - 1 Dec 1975

Keywords

  • clinical considerations
  • elderly
  • pharmacokinetics
  • review

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