Pharmacokinetics and pharmacodynamics of peptide antibiotics

Xingchen Bian, Xingyi Qu, Jing Zhang, Sue C. Nang, Phillip J. Bergen, Qi Tony. Zhou, Hak Kim Chan, Meiqing Feng, Jian Li

Research output: Contribution to journalReview ArticleResearchpeer-review

22 Citations (Scopus)

Abstract

Antimicrobial resistance is a major global health challenge. As few new efficacious antibiotics will become available in the near future, peptide antibiotics continue to be major therapeutic options for treating infections caused by multidrug-resistant pathogens. Rational use of antibiotics requires optimisation of the pharmacokinetics and pharmacodynamics for the treatment of different types of infections. Toxicodynamics must also be considered to improve the safety of antibiotic use and, where appropriate, to guide therapeutic drug monitoring. This review focuses on the pharmacokinetics/pharmacodynamics/toxicodynamics of peptide antibiotics against multidrug-resistant Gram-negative and Gram-positive pathogens. Optimising antibiotic exposure at the infection site is essential for improving their efficacy and minimising emergence of resistance.

Original languageEnglish
Article number114171
Number of pages27
JournalAdvanced Drug Delivery Reviews
Volume183
DOIs
Publication statusPublished - Apr 2022

Keywords

  • Antibiotics
  • Antimicrobial peptide
  • Antimicrobial resistance
  • Pharmacodynamics
  • Pharmacokinetics
  • Safety
  • Therapeutic drug monitoring

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