Pharmacokinetics and Pharmacodynamics of Antibiotics in Bone

Cornelia B. Landersdorfer, Jürgen B. Bulitta, Fritz Sörgel

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

6 Citations (Scopus)

Abstract

Chronic osteomyelitis requires prolonged antibiotic treatment, has a high recurrence rate, and can cause irreversible damage. This chapter reviews the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics in bone and presents methods that support optimized evidence-based selection of antibiotic dosage regimens. PK processes include drug absorption from the site of administration into the systemic circulation, distribution from the systemic circulation into tissues, and elimination via metabolism, renal excretion, or both. PD describes the relationship between drug concentrations in plasma or at the target site and the time course of drug effect(s). Once a population PK model has been developed, it can be employed in Monte Carlo simulations to predict the expected concentration time profiles for other than the studied dosage regimens. The probability of achieving a PK/PD target can be predicted and recommendations be made on how to dose an antibiotic to maximize the probability of successful therapeutic outcome.

Original languageEnglish
Title of host publicationBone and Joint Infections
Subtitle of host publicationFrom Microbiology to Diagnostics and Treatment
EditorsWerner Zimmerli
Place of PublicationChichester UK
PublisherJohn Wiley & Sons
Pages21-37
Number of pages17
ISBN (Electronic)9781118581742
ISBN (Print)9781118581773
DOIs
Publication statusPublished - 30 Jan 2015

Keywords

  • Antibiotic dosage regimens
  • Monte Carlo simulations
  • Pharmacodynamics (PD)
  • Pharmacokinetics (PK)
  • Plasma and bone
  • Systemic circulation

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