Abstract
Chronic osteomyelitis requires prolonged antibiotic treatment, has a high recurrence rate, and can cause irreversible damage. This chapter reviews the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics in bone and presents methods that support optimized evidence-based selection of antibiotic dosage regimens. PK processes include drug absorption from the site of administration into the systemic circulation, distribution from the systemic circulation into tissues, and elimination via metabolism, renal excretion, or both. PD describes the relationship between drug concentrations in plasma or at the target site and the time course of drug effect(s). Once a population PK model has been developed, it can be employed in Monte Carlo simulations to predict the expected concentration time profiles for other than the studied dosage regimens. The probability of achieving a PK/PD target can be predicted and recommendations be made on how to dose an antibiotic to maximize the probability of successful therapeutic outcome.
| Original language | English |
|---|---|
| Title of host publication | Bone and Joint Infections |
| Subtitle of host publication | From Microbiology to Diagnostics and Treatment |
| Editors | Werner Zimmerli |
| Place of Publication | Chichester UK |
| Publisher | John Wiley & Sons |
| Pages | 21-37 |
| Number of pages | 17 |
| ISBN (Electronic) | 9781118581742 |
| ISBN (Print) | 9781118581773 |
| DOIs | |
| Publication status | Published - 30 Jan 2015 |
Keywords
- Antibiotic dosage regimens
- Monte Carlo simulations
- Pharmacodynamics (PD)
- Pharmacokinetics (PK)
- Plasma and bone
- Systemic circulation
Cite this
}
Pharmacokinetics and Pharmacodynamics of Antibiotics in Bone. / Landersdorfer, Cornelia B.; Bulitta, Jürgen B.; Sörgel, Fritz.
Bone and Joint Infections: From Microbiology to Diagnostics and Treatment. ed. / Werner Zimmerli. Chichester UK : John Wiley & Sons, 2015. p. 21-37.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
TY - CHAP
T1 - Pharmacokinetics and Pharmacodynamics of Antibiotics in Bone
AU - Landersdorfer, Cornelia B.
AU - Bulitta, Jürgen B.
AU - Sörgel, Fritz
PY - 2015/1/30
Y1 - 2015/1/30
N2 - Chronic osteomyelitis requires prolonged antibiotic treatment, has a high recurrence rate, and can cause irreversible damage. This chapter reviews the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics in bone and presents methods that support optimized evidence-based selection of antibiotic dosage regimens. PK processes include drug absorption from the site of administration into the systemic circulation, distribution from the systemic circulation into tissues, and elimination via metabolism, renal excretion, or both. PD describes the relationship between drug concentrations in plasma or at the target site and the time course of drug effect(s). Once a population PK model has been developed, it can be employed in Monte Carlo simulations to predict the expected concentration time profiles for other than the studied dosage regimens. The probability of achieving a PK/PD target can be predicted and recommendations be made on how to dose an antibiotic to maximize the probability of successful therapeutic outcome.
AB - Chronic osteomyelitis requires prolonged antibiotic treatment, has a high recurrence rate, and can cause irreversible damage. This chapter reviews the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics in bone and presents methods that support optimized evidence-based selection of antibiotic dosage regimens. PK processes include drug absorption from the site of administration into the systemic circulation, distribution from the systemic circulation into tissues, and elimination via metabolism, renal excretion, or both. PD describes the relationship between drug concentrations in plasma or at the target site and the time course of drug effect(s). Once a population PK model has been developed, it can be employed in Monte Carlo simulations to predict the expected concentration time profiles for other than the studied dosage regimens. The probability of achieving a PK/PD target can be predicted and recommendations be made on how to dose an antibiotic to maximize the probability of successful therapeutic outcome.
KW - Antibiotic dosage regimens
KW - Monte Carlo simulations
KW - Pharmacodynamics (PD)
KW - Pharmacokinetics (PK)
KW - Plasma and bone
KW - Systemic circulation
UR - http://www.scopus.com/inward/record.url?scp=85016056911&partnerID=8YFLogxK
U2 - 10.1002/9781118581742.ch3
DO - 10.1002/9781118581742.ch3
M3 - Chapter (Book)
SN - 9781118581773
SP - 21
EP - 37
BT - Bone and Joint Infections
A2 - Zimmerli, Werner
PB - John Wiley & Sons
CY - Chichester UK
ER -