TY - JOUR
T1 - Pharmacokinetic properties of captopril after acute and chronic administration to hypertensive subjects
AU - Jarrott, Bevyn
AU - Drummer, Olaf
AU - Hooper, Rita
AU - Anderson, Adrianne I.E.
AU - Miach, Peter J.
AU - Louis, William J.
N1 - WOS DocType=Note
PY - 1982/4/21
Y1 - 1982/4/21
N2 - The pharmacokinetic properties of captopril were studied in two groups of hypertensive patients: (1) those who had never taken captopril (acute group), and (2) those who had been taking captopril for at least 6 months (chronic group). It was found that after 100 mg of captopril orally, the mean peak plasma level in the chronic group was three times higher than that in the acute group while the area under the curve was twice as high in the chronic group. These data suggest that bioavailability increases with chronic administration, and thus it may be possible to reduce the dosage of captopril and still maintain blood pressure control while reducing side effects.
AB - The pharmacokinetic properties of captopril were studied in two groups of hypertensive patients: (1) those who had never taken captopril (acute group), and (2) those who had been taking captopril for at least 6 months (chronic group). It was found that after 100 mg of captopril orally, the mean peak plasma level in the chronic group was three times higher than that in the acute group while the area under the curve was twice as high in the chronic group. These data suggest that bioavailability increases with chronic administration, and thus it may be possible to reduce the dosage of captopril and still maintain blood pressure control while reducing side effects.
UR - https://www.scopus.com/pages/publications/0019987626
U2 - 10.1016/0002-9149(82)90385-X
DO - 10.1016/0002-9149(82)90385-X
M3 - Article
C2 - 6803565
AN - SCOPUS:0019987626
SN - 0002-9149
VL - 49
SP - 1547
EP - 1549
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 6
ER -