Abstract
Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli-responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH-responsive nanoparticles are discussed, focusing on the use of charge-shifting polymers, acid labile linkages, and crosslinking.
| Original language | English |
|---|---|
| Article number | 1800917 |
| Number of pages | 23 |
| Journal | Macromolecular Rapid Communications |
| Volume | 40 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1 May 2019 |
Keywords
- charge shifting
- drug delivery
- pH-cleavable
- pH-responsive nanoparticles
- stimuli-responsive
Cite this
}
pH-Responsive Polymer Nanoparticles for Drug Delivery. / Deirram, Nayeleh; Zhang, Changhe; Kermaniyan, Sarah S.; Johnston, Angus P.R.; Such, Georgina K.
In: Macromolecular Rapid Communications, Vol. 40, No. 10, 1800917, 01.05.2019.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - pH-Responsive Polymer Nanoparticles for Drug Delivery
AU - Deirram, Nayeleh
AU - Zhang, Changhe
AU - Kermaniyan, Sarah S.
AU - Johnston, Angus P.R.
AU - Such, Georgina K.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli-responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH-responsive nanoparticles are discussed, focusing on the use of charge-shifting polymers, acid labile linkages, and crosslinking.
AB - Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli-responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH-responsive nanoparticles are discussed, focusing on the use of charge-shifting polymers, acid labile linkages, and crosslinking.
KW - charge shifting
KW - drug delivery
KW - pH-cleavable
KW - pH-responsive nanoparticles
KW - stimuli-responsive
UR - http://www.scopus.com/inward/record.url?scp=85062563026&partnerID=8YFLogxK
U2 - 10.1002/marc.201800917
DO - 10.1002/marc.201800917
M3 - Review Article
VL - 40
JO - Macromolecular Rapid Communications
JF - Macromolecular Rapid Communications
SN - 1022-1336
IS - 10
M1 - 1800917
ER -