pH-Responsive Polymer Nanoparticles for Drug Delivery

Nayeleh Deirram; Changhe Zhang; Sarah S. Kermaniyan; Angus P.R. Johnston; Georgina K. Such

doi:10.1002/marc.201800917

pH-Responsive Polymer Nanoparticles for Drug Delivery

Nayeleh Deirram, Changhe Zhang, Sarah S. Kermaniyan, Angus P.R. Johnston, Georgina K. Such

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Review Article › Research › peer-review

96 Citations (Scopus)

Abstract

Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli-responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH-responsive nanoparticles are discussed, focusing on the use of charge-shifting polymers, acid labile linkages, and crosslinking.

Original language	English
Article number	1800917
Number of pages	23
Journal	Macromolecular Rapid Communications
Volume	40
Issue number	10
DOIs	https://doi.org/10.1002/marc.201800917
Publication status	Published - 1 May 2019

Keywords

charge shifting
drug delivery
pH-cleavable
pH-responsive nanoparticles
stimuli-responsive

Access to Document

10.1002/marc.201800917

281702458-oaFinal published version, 5.02 MB

Link to publication in Scopus

Cite this

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AU - Such, Georgina K.

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AB - Stimuli-responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli-responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH-responsive nanoparticles are discussed, focusing on the use of charge-shifting polymers, acid labile linkages, and crosslinking.

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