pH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment

Renata Negrini, Wye-Khay Fong, Ben J Boyd, Raffaele Mezzenga

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Abstract

A weak amphiphilic base, pyridinylmethyl linoleate, is blended with monolinolein, yielding mesophases with a pH-induced hexagonal-to-cubic transition at pH ≤ 5.5. We show the potential therapeutic role of this mesophase in treating cancerous tissues exploiting their more acidic pH compared to healthy tissues. In vitro release studies with doxorubicin on HT29 human colon cancer cells show a 10-fold faster release and 3-fold increased efficiency for killing cancer cells at pH 5.5 versus pH 7.4, demonstrating the potential of this strategy in cancer treatment.
Original languageEnglish
Pages (from-to)6671-6674
Number of pages4
JournalChemical Communications
Volume51
Issue number30
DOIs
Publication statusPublished - 2015

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