pH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment

Renata Negrini; Wye-Khay Fong; Ben J Boyd; Raffaele Mezzenga

doi:10.1039/c4cc10274f

pH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment

Renata Negrini, Wye-Khay Fong, Ben J Boyd, Raffaele Mezzenga

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

82 Citations (Scopus)

Abstract

A weak amphiphilic base, pyridinylmethyl linoleate, is blended with monolinolein, yielding mesophases with a pH-induced hexagonal-to-cubic transition at pH ≤ 5.5. We show the potential therapeutic role of this mesophase in treating cancerous tissues exploiting their more acidic pH compared to healthy tissues. In vitro release studies with doxorubicin on HT29 human colon cancer cells show a 10-fold faster release and 3-fold increased efficiency for killing cancer cells at pH 5.5 versus pH 7.4, demonstrating the potential of this strategy in cancer treatment.

Original language	English
Pages (from-to)	6671-6674
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	30
DOIs	https://doi.org/10.1039/c4cc10274f
Publication status	Published - 2015

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abstract = "A weak amphiphilic base, pyridinylmethyl linoleate, is blended with monolinolein, yielding mesophases with a pH-induced hexagonal-to-cubic transition at pH ≤ 5.5. We show the potential therapeutic role of this mesophase in treating cancerous tissues exploiting their more acidic pH compared to healthy tissues. In vitro release studies with doxorubicin on HT29 human colon cancer cells show a 10-fold faster release and 3-fold increased efficiency for killing cancer cells at pH 5.5 versus pH 7.4, demonstrating the potential of this strategy in cancer treatment.",

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AU - Fong, Wye-Khay

AU - Boyd, Ben J

AU - Mezzenga, Raffaele

PY - 2015

Y1 - 2015

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AB - A weak amphiphilic base, pyridinylmethyl linoleate, is blended with monolinolein, yielding mesophases with a pH-induced hexagonal-to-cubic transition at pH ≤ 5.5. We show the potential therapeutic role of this mesophase in treating cancerous tissues exploiting their more acidic pH compared to healthy tissues. In vitro release studies with doxorubicin on HT29 human colon cancer cells show a 10-fold faster release and 3-fold increased efficiency for killing cancer cells at pH 5.5 versus pH 7.4, demonstrating the potential of this strategy in cancer treatment.

UR - http://pubs.rsc.org.ezproxy.lib.monash.edu.au/en/content/articlepdf/2015/cc/c4cc10274f

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DO - 10.1039/c4cc10274f

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EP - 6674

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 30

ER -

pH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment

Abstract

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