pH-Responsive, Amphiphilic Core-Shell Supramolecular Polymer Brushes from Cyclic Peptide-Polymer Conjugates

Sophie C. Larnaudie, Johannes C. Brendel, Katrina A. Jolliffe, Sébastien Perrier

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28 Citations (Scopus)

Abstract

The synthesis and self-assembly of pH-responsive, amphiphilic cyclic peptide-polymer conjugates are described. The design relies on the introduction of a poly(2-(diisopropylamino)ethyl methacrylate) (pDPA) block between the cyclic peptide and a hydrophilic block. These conjugates are disassembled and protonated at low pH but assemble into core-shell nanotubes at physiological pH, as determined by a combination of titration experiments and scattering techniques.

Original languageEnglish
Pages (from-to)1347-1351
Number of pages5
JournalACS Macro Letters
Volume6
Issue number12
DOIs
Publication statusPublished - 19 Dec 2017

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