TY - JOUR
T1 - Petrobactin biosynthesis
T2 - AsbB catalyzes condensation of spermidine with N8-citryl-spermidine and its N1-(3,4-dihydroxybenzoyl) derivative
AU - Oves-Costales, Daniel
AU - Kadi, Nadia
AU - Fogg, Mark J.
AU - Song, Lijiang
AU - Wilson, Keith S.
AU - Challis, Gregory L.
PY - 2008/9/8
Y1 - 2008/9/8
N2 - The AsbB enzyme, which is involved in the biosynthesis of the virulence-conferring siderophore petrobactin in Bacillus anthracis, is shown to catalyze efficient ATP-dependent condensation of spermidine, but not N 1-(3,4-dihydroxbenzoyl)-spermidine, with N8-citryl- spermidine or N1-(3,4-dihydroxbenzoyl)-N8-citryl- spermidine, suggesting that N1-(3,4-dihydroxbenzoyl)-spermidine is very unlikely to be a significant intermediate in petrobactin biosynthesis, contrary to previous suggestions.
AB - The AsbB enzyme, which is involved in the biosynthesis of the virulence-conferring siderophore petrobactin in Bacillus anthracis, is shown to catalyze efficient ATP-dependent condensation of spermidine, but not N 1-(3,4-dihydroxbenzoyl)-spermidine, with N8-citryl- spermidine or N1-(3,4-dihydroxbenzoyl)-N8-citryl- spermidine, suggesting that N1-(3,4-dihydroxbenzoyl)-spermidine is very unlikely to be a significant intermediate in petrobactin biosynthesis, contrary to previous suggestions.
UR - https://www.scopus.com/pages/publications/50849126499
U2 - 10.1039/b809353a
DO - 10.1039/b809353a
M3 - Article
C2 - 18758617
AN - SCOPUS:50849126499
SN - 1359-7345
SP - 4034
EP - 4036
JO - Chemical Communications
JF - Chemical Communications
IS - 34
ER -