TY - JOUR
T1 - Perspectives on Scedosporium species and Lomentospora prolificans in lung transplantation
T2 - Results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology
AU - Rammaert, Blandine
AU - Puyade, Mathieu
AU - Cornely, Oliver A.
AU - Seidel, Danila
AU - Grossi, Paolo
AU - Husain, Shahid
AU - Picard, Clément
AU - Lass-Flörl, Cornelia
AU - Manuel, Oriol
AU - Le Pavec, Jérôme
AU - Lortholary, Olivier
AU - Nagel, Claudia
AU - Westall, Glen
AU - Morrissey, Orla
AU - Chambers, Daniel
AU - Eschertzhuber, Stephan
AU - Coussement, Julien
AU - Knoop, Christiane
AU - Vos, Robin
AU - Dupont, Lieven
AU - Dumonceaux, Michel
AU - Campos, Silvia Vidal
AU - Kabbani, Dima
AU - Cervera, Carlos
AU - Luong, Me Linh
AU - Blanchard, Elodie
AU - Sénéchal, Agathe
AU - Pavec, Jérôme Le
AU - Brugière, Olivier
AU - Boussaud, Veronique
AU - Guillemain, Romain
AU - Bervar, Jean Francois
AU - Claustre, Johanna
AU - Haloun, Alain
AU - Hirschi, Sandrine
AU - Reynaud, Martine
AU - Kneidinger, Nikolaus
AU - Gottlieb, Jens
AU - Roilides, Emmanuel
AU - Zarrinfar, Hossein
AU - Rosso, Lorenzo
AU - Morlacchi, Letizia Corinna
AU - Dell'Amore, Andrea
AU - Loy, Monica
AU - Santos, Claudy Oliveira dos
AU - Rello, Jordi
AU - Monforte, Victor
AU - Martin-Gomez, Maria Teresa
AU - Medrano, Francisco López
AU - Fernández-Ruiz, Mario
AU - Sole, Amparo
AU - Cifrian, Jose M.
AU - Neofytos, Dionysios
AU - Mueller, Nicolas
AU - Benden, Christian
AU - Brill, Anne Kathrin
AU - Kiyan, Esen
AU - Gould, Kate
AU - Gkrania-Klotsas, Effrossyni
AU - David, Miruna
AU - Weigt, Sam
AU - Kwak, Eun Jeong
AU - Silveira, Fernanda
AU - Hadjiliadis, Denis
AU - Baddley, John
AU - Danziger-Isakov, Lara
AU - Bhorade, Sangeeta
AU - Ison, Michael
AU - Wolfe, Cameron
AU - Aslam, Saima
AU - Budem, Marie
AU - Musetti, Ana
AU - the SCEDO-LUNG collaborative group
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Background: Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients. Methods: We assessed the current practices on management of S/L colonization/infection of the lower respiratory tract before and after lung transplantation in a large number of lung transplant centers through an international practice survey from October 2016 to March 2017. Results: A total of 51 respondents from 45 lung transplant centers (17 countries, 4 continents) answered the survey (response rate 58%). S/L colonization was estimated to be detected in candidates by 48% of centers. Only 18% of the centers used a specific medium to detect S/L colonization. Scedosporium spp. colonization was a contraindication to transplantation in 10% of centers whereas L prolificans was a contraindication in 31%; 22% of centers declared having had 1-5 recipients infected with S/L in the past 5 years. Conclusions: This survey gives an overview of the current practices regarding S/L colonization and infection in lung transplant centers worldwide and underscores the need of S/L culture procedure standardization before implementing prospective studies.
AB - Background: Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients. Methods: We assessed the current practices on management of S/L colonization/infection of the lower respiratory tract before and after lung transplantation in a large number of lung transplant centers through an international practice survey from October 2016 to March 2017. Results: A total of 51 respondents from 45 lung transplant centers (17 countries, 4 continents) answered the survey (response rate 58%). S/L colonization was estimated to be detected in candidates by 48% of centers. Only 18% of the centers used a specific medium to detect S/L colonization. Scedosporium spp. colonization was a contraindication to transplantation in 10% of centers whereas L prolificans was a contraindication in 31%; 22% of centers declared having had 1-5 recipients infected with S/L in the past 5 years. Conclusions: This survey gives an overview of the current practices regarding S/L colonization and infection in lung transplant centers worldwide and underscores the need of S/L culture procedure standardization before implementing prospective studies.
KW - invasive fungal disease
KW - lomentosporiosis
KW - scedosporiosis
KW - solid organ transplantation
UR - http://www.scopus.com/inward/record.url?scp=85069887016&partnerID=8YFLogxK
U2 - 10.1111/tid.13141
DO - 10.1111/tid.13141
M3 - Article
C2 - 31283872
AN - SCOPUS:85069887016
SN - 1398-2273
VL - 21
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
IS - 5
M1 - e13141
ER -