Prostate cancer is a commonly diagnosed cancer in men. Few men understand the complexities involved with prostate screening and treatment issues. The information that men seek and obtain may influence how they make decisions about prostate cancer. The objective of this study was to explore men s knowledge, information seeking and decision-making behaviour in relation to prostate cancer. Methods: A qualitative design with the use of focus groups was adopted for this study. A total of 11 focus groups were conducted with 76 men. Each focus group was specific with regards to cancer diagnosis (with and without) and setting (rural or metropolitan). All focus group discussions were conducted by the same moderator and audio-taped. Transcriptions were analysed according to the grounded theory approach. Results: Participants knowledge about prostate cancer and relevant treatments was low, despite a large awareness about tests. Patient education resources to facilitate informed decision making were highly valued. The internet was a primary source of information for prostate cancer patients. Patient education materials enabled a proactive approach to medical decision making. Participants demonstrated a preference to discuss treatment options with a health professional, independent of their treating doctor, to assist with decision making. Conclusions: Men adopt a multi-factorial approach to decision making with respect to prostate cancer. The role of a health knowledge broker to independently assist patients may facilitate increased patient knowledge, awareness and decision making regarding prostate cancer treatment.