Perspective and potential of oral lipid-based delivery to optimize pharmacological therapies against cardiovascular diseases

Shasha Rao, Angel Tan, Nicky Thomas, Clive A. Prestidge

Research output: Contribution to journalReview ArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Cardiovascular diseases (CVDs) remain the major cause of morbidity and mortality globally. Despite the large number of cardiovascular drugs available for pharmacological therapies, factors limiting the efficient oral use are identified, including low water solubility, pre-systemic metabolism, food intake effects and short half-life. Numerous in vivo proof-of-concepts studies are presented to highlight the viability of lipid-based delivery to optimize the oral delivery of cardiovascular drugs. In particular, the key performance enhancement roles of oral lipid-based drug delivery systems (LBDDSs) are identified, which include i) improving the oral bioavailability, ii) sustaining controlling drug release, iii) improving drug stability, iv) reducing food intake effect, v) targeting to injured sites, and vi) potential for combination therapy. Mechanisms involved in achieving these features, range of applicability, and limits of available systems are detailed. Future research and development efforts to address these issues are discussed, which is of significant value in directing future research work in fostering translation of lipid-based formulations into clinical applications to reduce the prevalence of CVDs.

Original languageEnglish
Pages (from-to)174-187
Number of pages14
JournalJournal of Controlled Release
Volume193
DOIs
Publication statusPublished - 10 Nov 2014
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Combined therapy
  • Controlled drug release
  • Lipid-based drug delivery
  • Oral bioavailability
  • Targeted delivery

Cite this