Persistent immune activation in chronic HIV infection: do any interventions work?

Reena Rajasuriar, Gabriela Khoury, Adeeba Binti Kamarulzaman, Martyn A French, Paul Urquhart Cameron, Sharon R Lewin

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

Abstract

Persistent immune activation (IA) is a hallmark of chronic HIV infection. IA has been associated with poor CD4 T-cell recovery, non-AIDS defining illnesses and mortality during combination antiretroviral therapy (cART). Measures of chronic immune activation, namely T-cell activation and more recently monocyte activation and plasma inflammatory and thrombotic biomarkers, have all been shown to remain elevated despite years of suppressive cART. Here we review recent clinical trials and therapeutic approaches targeted to reduce persistent IA in HIV patients and discuss the impact of each of these approaches on clinically relevant end-points.
Original languageEnglish
Pages (from-to)1199 - 1208
Number of pages10
JournalAIDS
Volume27
Issue number8
DOIs
Publication statusPublished - 2013

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