Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: A case study and review

G. Grigoriadis, J. Condon, K. Green, M. A. Anderson, M. Borosak, Erica Wood

Research output: Contribution to journalArticleOther

Abstract

AnWj is a high-incidence antigen present on the red blood cells (RBCs) of greater than 99 percent of the general population. A 58-year-old man underwent autologous hematopoietic stem cell transplantation (HSCT) for stage IVa mantle cell lymphoma. This procedure was complicated by failure to engraft, necessitating ongoing support with blood components. After a 2-month period of uneventful transfusion support, the patient experienced increasingly severe reactions with fever and evidence of intravascular hemolysis, including hemoglobinuria. Testing revealed a complement-dependent anti-AnWj. Phenotyping confirmed the AnWja?? phenotype. Anti-AnWj was persistent despite immunosuppression, including treatment with allogeneic HSCT. Of interest, the pathogenesis of the downregulation of the graft AnWj in this patient is unclear.
Original languageEnglish
Pages (from-to)83 - 88
Number of pages6
JournalImmunohematology
Volume27
Issue number3
DOIs
Publication statusPublished - 2011

Cite this

Grigoriadis, G. ; Condon, J. ; Green, K. ; Anderson, M. A. ; Borosak, M. ; Wood, Erica. / Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder : A case study and review. In: Immunohematology. 2011 ; Vol. 27, No. 3. pp. 83 - 88.
@article{66496654bab842c196ad767f6194f6f7,
title = "Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: A case study and review",
abstract = "AnWj is a high-incidence antigen present on the red blood cells (RBCs) of greater than 99 percent of the general population. A 58-year-old man underwent autologous hematopoietic stem cell transplantation (HSCT) for stage IVa mantle cell lymphoma. This procedure was complicated by failure to engraft, necessitating ongoing support with blood components. After a 2-month period of uneventful transfusion support, the patient experienced increasingly severe reactions with fever and evidence of intravascular hemolysis, including hemoglobinuria. Testing revealed a complement-dependent anti-AnWj. Phenotyping confirmed the AnWja?? phenotype. Anti-AnWj was persistent despite immunosuppression, including treatment with allogeneic HSCT. Of interest, the pathogenesis of the downregulation of the graft AnWj in this patient is unclear.",
author = "G. Grigoriadis and J. Condon and K. Green and Anderson, {M. A.} and M. Borosak and Erica Wood",
year = "2011",
doi = "10.1111/j.1537-2995.2008.01944.x",
language = "English",
volume = "27",
pages = "83 -- 88",
journal = "Immunohematology",
issn = "0894-203X",
number = "3",

}

Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder : A case study and review. / Grigoriadis, G.; Condon, J.; Green, K.; Anderson, M. A.; Borosak, M.; Wood, Erica.

In: Immunohematology, Vol. 27, No. 3, 2011, p. 83 - 88.

Research output: Contribution to journalArticleOther

TY - JOUR

T1 - Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder

T2 - A case study and review

AU - Grigoriadis, G.

AU - Condon, J.

AU - Green, K.

AU - Anderson, M. A.

AU - Borosak, M.

AU - Wood, Erica

PY - 2011

Y1 - 2011

N2 - AnWj is a high-incidence antigen present on the red blood cells (RBCs) of greater than 99 percent of the general population. A 58-year-old man underwent autologous hematopoietic stem cell transplantation (HSCT) for stage IVa mantle cell lymphoma. This procedure was complicated by failure to engraft, necessitating ongoing support with blood components. After a 2-month period of uneventful transfusion support, the patient experienced increasingly severe reactions with fever and evidence of intravascular hemolysis, including hemoglobinuria. Testing revealed a complement-dependent anti-AnWj. Phenotyping confirmed the AnWja?? phenotype. Anti-AnWj was persistent despite immunosuppression, including treatment with allogeneic HSCT. Of interest, the pathogenesis of the downregulation of the graft AnWj in this patient is unclear.

AB - AnWj is a high-incidence antigen present on the red blood cells (RBCs) of greater than 99 percent of the general population. A 58-year-old man underwent autologous hematopoietic stem cell transplantation (HSCT) for stage IVa mantle cell lymphoma. This procedure was complicated by failure to engraft, necessitating ongoing support with blood components. After a 2-month period of uneventful transfusion support, the patient experienced increasingly severe reactions with fever and evidence of intravascular hemolysis, including hemoglobinuria. Testing revealed a complement-dependent anti-AnWj. Phenotyping confirmed the AnWja?? phenotype. Anti-AnWj was persistent despite immunosuppression, including treatment with allogeneic HSCT. Of interest, the pathogenesis of the downregulation of the graft AnWj in this patient is unclear.

UR - http://a1881.g.akamai.net/7/1881/26640/v0001/redcross.download.akamai.com/26640/pubs/immuno/27_3_11.pdf

U2 - 10.1111/j.1537-2995.2008.01944.x

DO - 10.1111/j.1537-2995.2008.01944.x

M3 - Article

VL - 27

SP - 83

EP - 88

JO - Immunohematology

JF - Immunohematology

SN - 0894-203X

IS - 3

ER -