Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: A case study and review

G. Grigoriadis, J. Condon, K. Green, M. A. Anderson, M. Borosak, Erica Wood

Research output: Contribution to journalArticleOther

4 Citations (Scopus)

Abstract

AnWj is a high-incidence antigen present on the red blood cells (RBCs) of greater than 99 percent of the general population. A 58-year-old man underwent autologous hematopoietic stem cell transplantation (HSCT) for stage IVa mantle cell lymphoma. This procedure was complicated by failure to engraft, necessitating ongoing support with blood components. After a 2-month period of uneventful transfusion support, the patient experienced increasingly severe reactions with fever and evidence of intravascular hemolysis, including hemoglobinuria. Testing revealed a complement-dependent anti-AnWj. Phenotyping confirmed the AnWja?? phenotype. Anti-AnWj was persistent despite immunosuppression, including treatment with allogeneic HSCT. Of interest, the pathogenesis of the downregulation of the graft AnWj in this patient is unclear.
Original languageEnglish
Pages (from-to)83 - 88
Number of pages6
JournalImmunohematology
Volume27
Issue number3
DOIs
Publication statusPublished - 2011

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