Persistence and function of central and effector memory CD4+ T cells following infection with a gastrointestinal helminth

Colby Zaph, Kathryn A. Rook, Michael Goldschmidt, Markus Mohrs, Phillip Scott, David Artis

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Abstract

Immunity in the gastrointestinal tract is important for resistance to many pathogens, but the memory T cells that mediate such immunity are poorly characterized. In this study, we show that following sterile cure of a primary infection with the gastrointestinal parasite Trichuris muris, memory CD4 + T cells persist in the draining mesenteric lymph node and protect mice against reinfection. The memory CD4+ T cells that developed were a heterogeneous population, consisting of both CD62Lhigh central memory T cells (TCM) and CD62Llow effector memory T cells (TEM) that were competent to produce the Th type 2 effector cytokine, IL-4. Unlike memory T cells that develop following exposure to several other pathogens, both CD4+ TCM and TEM populations persisted in the absence of chronic infection, and, critically, both populations were able to transfer protective immunity to naive recipients. CB62L highCD4+ TCM were not apparent early after infection, but emerged following clearance of primary infection, suggesting that they may be derived from CD4+ TEM. Consistent with this theory, transfer of CD62LlowCD4+ TEM into naive recipients resulted in the development of a population of protective CD62L highCD4+ TCM. Taken together, these studies show that distinct subsets of memory CD4+ T cells develop after infection with Trichuris, persist in the GALT, and mediate protective immunity to rechallenge.

Original languageEnglish
Pages (from-to)511-518
Number of pages8
JournalJournal of Immunology
Volume177
Issue number1
Publication statusPublished - 1 Jul 2006
Externally publishedYes

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