Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder

Karen Blackmon, Emma Ben-Avi, Xiuyuan Wang, Heath R. Pardoe, Adriana Di Martino, Eric Halgren, Orrin Devinsky, Thomas Thesen, Ruben Kuzniecky

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21 Citations (Scopus)


Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans. This may be due to the visually elusive nature of many malformations on MRI. Here, we utilize a quantitative approach to determine whether a volumetric measure of heterotopic gray matter in the white matter is elevated in people with ASD, relative to typically developing controls (TDC). Data from a primary sample of 48 children/young adults with ASD and 48 age-, and gender-matched TDCs, selected from the Autism Brain Imaging Data Exchange (ABIDE) open-access database, were analyzed to compare groups on (1) blinded review of high-resolution T1-weighted research sequences; and (2) quantitative measurement of white matter hypointensity (WMH) volume calculated from the same T1-weighted scans. Groupwise WMH volume comparisons were repeated in an independent, multi-site sample (80 ASD/80 TDC), also selected from ABIDE. Visual review resulted in equivalent proportions of imaging abnormalities in the ASD and TDC group. However, quantitative analysis revealed elevated periventricular and deep subcortical WMH volumes in ASD. This finding was replicated in the independent, multi-site sample. Periventricular WMH volume was not associated with age but was associated with greater restricted repetitive behaviors on both parent-reported and clinician-rated assessment inventories. Thus, findings demonstrate that periventricular WMH volume is elevated in ASD and associated with a higher degree of repetitive behaviors and restricted interests. Although the etiology of focal WMH clusters is unknown, the absence of age effects suggests that they may reflect a static anomaly.

Original languageEnglish
Pages (from-to)36-45
Number of pages10
JournalNeuroImage: Clinical
Publication statusPublished - 1 Jan 2016
Externally publishedYes


  • Autism spectrum disorder
  • Magnetic resonance imaging
  • Malformations of cortical development
  • Periventricular heterotopia
  • Restricted repetitive behaviors
  • White matter hypointensities

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