Peripheral nerve binding patterns of anti-sulphatide antibodies in HIV- infected individuals

Steven Petratos, Victor J. Turnbull, Roula Papadopoulos, Margaret Ayers, Michael F. Gonzales

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

HIV-positive plasma samples from patients with and without neuropathy and with high titre anti-GalS antibodies showed strong binding to the myelin membrane of both fixed and unfixed human sciatic nerve specimens. This staining pattern was also seen with a plasma sample from a patient with IgM paraproteinaemic inflammatory demyelinating neuropathy with anti-GalS IgM antibody. Teased nerve fibres incubated with these anti-GalS antibodies from both HIV and non-HIV plasma samples showed immunofluorescence at the paranodal regions and Schmidt-Lanterman incisures. These data support a potential role for these antibodies in the aetiology of HIV-associated immune mediated neuropathies.

Original languageEnglish
Pages (from-to)1659-1664
Number of pages6
JournalNeuroReport
Volume10
Issue number8
DOIs
Publication statusPublished - 3 Jun 1999
Externally publishedYes

Keywords

  • Antibodies
  • Demyelination
  • HIV-associated peripheral neuropathy
  • Sulphatide

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