Perinatal risk factors associated with the obstructive sleep apnea syndrome in school-aged children born preterm

Ignacio E. Tapia, Justine Shults, Lex W. Doyle, Gillian M. Nixon, Christopher M. Cielo, Joel Traylor, Carole L. Marcus, Caffeine for Apnea of Prematurity-Sleep Study Group

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Study Objectives: The obstructive sleep apnea syndrome (OSAS) is more prevalent in ex-preterm children compared to the general pediatric population. However, it is unknown whether OSAS in ex-preterm children is associated with specific perinatal risk factors. This multicenter cohort study aimed to determine perinatal factors associated with OSAS at school age. Methods: 197 ex-preterm (500-1,250 g) children aged 5-12 y who participated as neonates in a double-blind, randomized clinical trial of caffeine versus placebo (Caffeine for Apnea of Prematurity) underwent comprehensive ambulatory polysomnography. A negative binomial regression model was used to identify perinatal risk factors associated with OSAS. Results: 19 children had OSAS (9.6%). Chorioamnionitis and multiple gestation were positively associated with OSAS with P values of 0.014 and 0.03, respectively. Maternal white race (P = 0.047) and maternal age (P = 0.002) were negatively associated with OSAS. Other risk factors, such as birth weight, Apgar score at 5 min, antenatal corticosteroids, delivery route, and sex were not significant. Conclusions: OSAS is very frequent, and is associated with chorioamnionitis and multiple gestation in ex-preterm children. Those born to older white mothers appear to be protected. We speculate that the former may be due to systemic inflammation and the latter to a higher socio-economic status.

Original languageEnglish
Pages (from-to)737-742
Number of pages6
JournalSleep
Volume39
Issue number4
DOIs
Publication statusPublished - 1 Apr 2016

Keywords

  • OSAS
  • Preterm
  • Risk factors
  • School-aged

Cite this

Tapia, I. E., Shults, J., Doyle, L. W., Nixon, G. M., Cielo, C. M., Traylor, J., ... Caffeine for Apnea of Prematurity-Sleep Study Group (2016). Perinatal risk factors associated with the obstructive sleep apnea syndrome in school-aged children born preterm. Sleep, 39(4), 737-742. https://doi.org/10.5665/sleep.5618
Tapia, Ignacio E. ; Shults, Justine ; Doyle, Lex W. ; Nixon, Gillian M. ; Cielo, Christopher M. ; Traylor, Joel ; Marcus, Carole L. ; Caffeine for Apnea of Prematurity-Sleep Study Group. / Perinatal risk factors associated with the obstructive sleep apnea syndrome in school-aged children born preterm. In: Sleep. 2016 ; Vol. 39, No. 4. pp. 737-742.
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abstract = "Study Objectives: The obstructive sleep apnea syndrome (OSAS) is more prevalent in ex-preterm children compared to the general pediatric population. However, it is unknown whether OSAS in ex-preterm children is associated with specific perinatal risk factors. This multicenter cohort study aimed to determine perinatal factors associated with OSAS at school age. Methods: 197 ex-preterm (500-1,250 g) children aged 5-12 y who participated as neonates in a double-blind, randomized clinical trial of caffeine versus placebo (Caffeine for Apnea of Prematurity) underwent comprehensive ambulatory polysomnography. A negative binomial regression model was used to identify perinatal risk factors associated with OSAS. Results: 19 children had OSAS (9.6{\%}). Chorioamnionitis and multiple gestation were positively associated with OSAS with P values of 0.014 and 0.03, respectively. Maternal white race (P = 0.047) and maternal age (P = 0.002) were negatively associated with OSAS. Other risk factors, such as birth weight, Apgar score at 5 min, antenatal corticosteroids, delivery route, and sex were not significant. Conclusions: OSAS is very frequent, and is associated with chorioamnionitis and multiple gestation in ex-preterm children. Those born to older white mothers appear to be protected. We speculate that the former may be due to systemic inflammation and the latter to a higher socio-economic status.",
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Tapia, IE, Shults, J, Doyle, LW, Nixon, GM, Cielo, CM, Traylor, J, Marcus, CL & Caffeine for Apnea of Prematurity-Sleep Study Group 2016, 'Perinatal risk factors associated with the obstructive sleep apnea syndrome in school-aged children born preterm' Sleep, vol. 39, no. 4, pp. 737-742. https://doi.org/10.5665/sleep.5618

Perinatal risk factors associated with the obstructive sleep apnea syndrome in school-aged children born preterm. / Tapia, Ignacio E.; Shults, Justine; Doyle, Lex W.; Nixon, Gillian M.; Cielo, Christopher M.; Traylor, Joel; Marcus, Carole L.; Caffeine for Apnea of Prematurity-Sleep Study Group.

In: Sleep, Vol. 39, No. 4, 01.04.2016, p. 737-742.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Tapia, Ignacio E.

AU - Shults, Justine

AU - Doyle, Lex W.

AU - Nixon, Gillian M.

AU - Cielo, Christopher M.

AU - Traylor, Joel

AU - Marcus, Carole L.

AU - Caffeine for Apnea of Prematurity-Sleep Study Group

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AB - Study Objectives: The obstructive sleep apnea syndrome (OSAS) is more prevalent in ex-preterm children compared to the general pediatric population. However, it is unknown whether OSAS in ex-preterm children is associated with specific perinatal risk factors. This multicenter cohort study aimed to determine perinatal factors associated with OSAS at school age. Methods: 197 ex-preterm (500-1,250 g) children aged 5-12 y who participated as neonates in a double-blind, randomized clinical trial of caffeine versus placebo (Caffeine for Apnea of Prematurity) underwent comprehensive ambulatory polysomnography. A negative binomial regression model was used to identify perinatal risk factors associated with OSAS. Results: 19 children had OSAS (9.6%). Chorioamnionitis and multiple gestation were positively associated with OSAS with P values of 0.014 and 0.03, respectively. Maternal white race (P = 0.047) and maternal age (P = 0.002) were negatively associated with OSAS. Other risk factors, such as birth weight, Apgar score at 5 min, antenatal corticosteroids, delivery route, and sex were not significant. Conclusions: OSAS is very frequent, and is associated with chorioamnionitis and multiple gestation in ex-preterm children. Those born to older white mothers appear to be protected. We speculate that the former may be due to systemic inflammation and the latter to a higher socio-economic status.

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