Abstract
A suboptimal perinatal environment can adversely influence gamete, embryonic, fetal, and infant development, setting in motion a train of events that increases the risk of hypertension and cardiovascular disease throughout life. This chapter summarizes the evidence linking an adverse maternal environment to developmental plasticity, in which the fetus adapts to the prevailing environmental conditions, subsequently altering the adult phenotype. Early studies linked low birth weight to the programming of high blood pressure. However, it is now evident that altered fetal development can also occur independently of low birth weight. Thus, the health implications of the maternal environment are much greater than predicted by the proportion of babies suffering growth restriction.We discuss both the stimuli and mechanisms that drive the perinatal programming of arterial pressure. We will consider kidney structure and function as a primary determinant of arterial pressure, as well as vascular, cardiac, and neural adaptations. Finally, therapeutic options to prevent, limit, or reverse these adverse consequences of a challenging start to life are explored.
| Original language | English |
|---|---|
| Title of host publication | Pediatric Hypertension |
| Editors | Joseph T. Flynn, Julie R. Ingelfinger, Karen M. Redwine |
| Publisher | Springer |
| Pages | 135-158 |
| Number of pages | 24 |
| ISBN (Electronic) | 9783319311074 |
| ISBN (Print) | 9783319311067 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
Keywords
- Arterial pressure
- Developmental programming
- Glucocorticoids
- Kidney
- Low-birth weight
- Maternal environment
- Maternal nutrition
- Nephron number
- Perinatal supplements
Cite this
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Perinatal programming of arterial pressure. / Singh, Reetu R.; Denton, Kate M.; Bertram, John F.
Pediatric Hypertension. ed. / Joseph T. Flynn; Julie R. Ingelfinger; Karen M. Redwine. Springer, 2018. p. 135-158.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
TY - CHAP
T1 - Perinatal programming of arterial pressure
AU - Singh, Reetu R.
AU - Denton, Kate M.
AU - Bertram, John F.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - A suboptimal perinatal environment can adversely influence gamete, embryonic, fetal, and infant development, setting in motion a train of events that increases the risk of hypertension and cardiovascular disease throughout life. This chapter summarizes the evidence linking an adverse maternal environment to developmental plasticity, in which the fetus adapts to the prevailing environmental conditions, subsequently altering the adult phenotype. Early studies linked low birth weight to the programming of high blood pressure. However, it is now evident that altered fetal development can also occur independently of low birth weight. Thus, the health implications of the maternal environment are much greater than predicted by the proportion of babies suffering growth restriction.We discuss both the stimuli and mechanisms that drive the perinatal programming of arterial pressure. We will consider kidney structure and function as a primary determinant of arterial pressure, as well as vascular, cardiac, and neural adaptations. Finally, therapeutic options to prevent, limit, or reverse these adverse consequences of a challenging start to life are explored.
AB - A suboptimal perinatal environment can adversely influence gamete, embryonic, fetal, and infant development, setting in motion a train of events that increases the risk of hypertension and cardiovascular disease throughout life. This chapter summarizes the evidence linking an adverse maternal environment to developmental plasticity, in which the fetus adapts to the prevailing environmental conditions, subsequently altering the adult phenotype. Early studies linked low birth weight to the programming of high blood pressure. However, it is now evident that altered fetal development can also occur independently of low birth weight. Thus, the health implications of the maternal environment are much greater than predicted by the proportion of babies suffering growth restriction.We discuss both the stimuli and mechanisms that drive the perinatal programming of arterial pressure. We will consider kidney structure and function as a primary determinant of arterial pressure, as well as vascular, cardiac, and neural adaptations. Finally, therapeutic options to prevent, limit, or reverse these adverse consequences of a challenging start to life are explored.
KW - Arterial pressure
KW - Developmental programming
KW - Glucocorticoids
KW - Kidney
KW - Low-birth weight
KW - Maternal environment
KW - Maternal nutrition
KW - Nephron number
KW - Perinatal supplements
UR - http://www.scopus.com/inward/record.url?scp=85046449448&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-31107-4_40
DO - 10.1007/978-3-319-31107-4_40
M3 - Chapter (Book)
SN - 9783319311067
SP - 135
EP - 158
BT - Pediatric Hypertension
A2 - Flynn, Joseph T.
A2 - Ingelfinger, Julie R.
A2 - Redwine, Karen M.
PB - Springer
ER -