Perilipin gene 1237 T>C polymorphism is not associated with obesity risk in Northern Chinese Han adults

Dong Sheng Hu, Jing Xie, Da Hai Yu, Guo Heng Xu, Jie Lu, Jin Xiu Yang, Chun Yang Li, Yan Yan Li

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5 Citations (Scopus)

Abstract

Objective: To identify the association between PLIN 1237 polymorphism and obesity in Chinese Han adults. Methods A total of 994 adults (157 obese subjects, 322 overweight subjects, and 515 normal controls) were recruited from two rural communities. PLIN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism (PCR-RFLP). Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression. Results: The three genotypes of PLIN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PLIN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PLIN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PLIN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC+TC genotype was 0.8 (0.4, 1.4) in women (P=0.4) and 0.6 (0.3, 1.3) in men (P=0.2) after adjustment for age, education, household income and alcohol consumption, smoking, and physical activity. Conclusion Chinese Han adults have a lower frequency of variant-allele C in PLIN 1237. PLIN 1237 T>C polymorphism is not significantly associated with obesity in northern Chinese adults.

Original languageEnglish
Pages (from-to)442-447
Number of pages6
JournalBiomedical and Environmental Sciences
Volume22
Issue number5
DOIs
Publication statusPublished - 1 Jan 2009
Externally publishedYes

Keywords

  • Obesity
  • Perilipin
  • Polymorphism

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