Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain

Carlie L. Cullen; Renee E. Pepper; Mackenzie T. Clutterbuck; Kimberley A. Pitman; Viola Oorschot; Loic Auderset; Alexander D. Tang; Georg Ramm; Ben Emery; Jennifer Rodger; Renaud B. Jolivet; Kaylene M. Young

doi:10.1016/j.celrep.2020.108641

Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain

Carlie L. Cullen, Renee E. Pepper, Mackenzie T. Clutterbuck, Kimberley A. Pitman, Viola Oorschot, Loic Auderset, Alexander D. Tang, Georg Ramm, Ben Emery, Jennifer Rodger, Renaud B. Jolivet, Kaylene M. Young

Cryo Electron Microscopy (CryoEM)

Research output: Contribution to journal › Article › Research › peer-review

52 Citations (Scopus)

Abstract

Cullen et al. show that mature brain cells, called oligodendrocytes, undergo ultrastructural changes during learning. They lengthen the nodes of Ranvier and compress the periaxonal space to speed up action potential conduction. They also report that faster information transfer speeds correlate with greater skill acquisition during learning.

Original language	English
Article number	108641
Number of pages	23
Journal	Cell Reports
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2020.108641
Publication status	Published - 19 Jan 2021

Keywords

action potential
computational modeling
conduction velocity
myelin
node of Ranvier
oligodendrocyte
periaxonal space
plasticity
spatial learning
transcranial magnetic stimulation

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10.1016/j.celrep.2020.108641Licence: CC BY-NC-ND

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title = "Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain",

abstract = "Cullen et al. show that mature brain cells, called oligodendrocytes, undergo ultrastructural changes during learning. They lengthen the nodes of Ranvier and compress the periaxonal space to speed up action potential conduction. They also report that faster information transfer speeds correlate with greater skill acquisition during learning.",

keywords = "action potential, computational modeling, conduction velocity, myelin, node of Ranvier, oligodendrocyte, periaxonal space, plasticity, spatial learning, transcranial magnetic stimulation",

author = "Cullen, {Carlie L.} and Pepper, {Renee E.} and Clutterbuck, {Mackenzie T.} and Pitman, {Kimberley A.} and Viola Oorschot and Loic Auderset and Tang, {Alexander D.} and Georg Ramm and Ben Emery and Jennifer Rodger and Jolivet, {Renaud B.} and Young, {Kaylene M.}",

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AU - Cullen, Carlie L.

AU - Pepper, Renee E.

AU - Clutterbuck, Mackenzie T.

AU - Pitman, Kimberley A.

AU - Oorschot, Viola

AU - Auderset, Loic

AU - Tang, Alexander D.

AU - Ramm, Georg

AU - Emery, Ben

AU - Rodger, Jennifer

AU - Jolivet, Renaud B.

AU - Young, Kaylene M.

PY - 2021/1/19

Y1 - 2021/1/19

N2 - Cullen et al. show that mature brain cells, called oligodendrocytes, undergo ultrastructural changes during learning. They lengthen the nodes of Ranvier and compress the periaxonal space to speed up action potential conduction. They also report that faster information transfer speeds correlate with greater skill acquisition during learning.

AB - Cullen et al. show that mature brain cells, called oligodendrocytes, undergo ultrastructural changes during learning. They lengthen the nodes of Ranvier and compress the periaxonal space to speed up action potential conduction. They also report that faster information transfer speeds correlate with greater skill acquisition during learning.

KW - action potential

KW - computational modeling

KW - conduction velocity

KW - myelin

KW - node of Ranvier

KW - oligodendrocyte

KW - periaxonal space

KW - plasticity

KW - spatial learning

KW - transcranial magnetic stimulation

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SN - 2211-1247

VL - 34

JO - Cell Reports

JF - Cell Reports

IS - 3

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ER -

Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain

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Keywords

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Ramaciotti Centre for Cryo-Electron Microscopy

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Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain

Abstract

Keywords

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