Perfusion MR imaging in adult neoplasia

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Abstract

Introduction Perfusion MR imaging is able to characterize brain tumor biology and other central nervous system (CNS) disorders through the underlying pathological and physiological changes that occur with tumor vasculature. Although the biology underlying brain tumor angiogenesis and vascular recruitment, along with the feedback loop with tumor hypoxia and necrosis, is extremely complex, there are some aspects of tumor physiology that can be quantified using perfusion MR imaging. In particular, some perfusion metrics can be used as surrogate markers of tumor angiogenesis and vascular permeability. Previous chapters describe the various techniques available for acquiring perfusion MRI data. The two most common techniques currently used in both clinical and research settings are T 1-weighted steady-state dynamic contrast-enhanced MRI (DCE-MRI) and T 2*-weighted dynamic susceptibility-weighted contrast-enhanced MRI (DSC-MRI). The advantages and disadvantages of each technique for characterizing tumor biology will be discussed; however-DSC-MRI is in more widespread use. The effects of vascular endothelial growth factor (VEGF)/vascular permeability factor and other growth factors on vascular permeability have been under investigation since Folkman first described the association between tumoral growth and angiogenesis.[1] Recent evidence suggests that vascular permeability and the presence of VEGF are important mediators of tumor growth in addition to angiogenesis.[2-5] Perfusion MRI can now measure parameters such as cerebral blood volume (CBV) and vascular permeability, which can be directly correlated with these histopathological changes as well as molecular markers such as VEGF.[6-9]

Original languageEnglish
Title of host publicationClinical MR Neuroimaging
Subtitle of host publicationPhysiological and Functional Techniques, Second Edition
PublisherCambridge University Press (Anthem Press)
Pages341-368
Number of pages28
ISBN (Electronic)9781139193481
ISBN (Print)9780521515634
DOIs
Publication statusPublished - 1 Jan 2011
Externally publishedYes

Cite this

Law, M. (2011). Perfusion MR imaging in adult neoplasia. In Clinical MR Neuroimaging: Physiological and Functional Techniques, Second Edition (pp. 341-368). Cambridge University Press (Anthem Press). https://doi.org/10.1017/CBO9781139193481.027