TY - JOUR
T1 - Performance of screening tests for esophageal squamous cell carcinoma
T2 - a systematic review and meta-analysis
AU - Wong, Martin C.S.
AU - Deng, Yunyang
AU - Huang, Junjie
AU - Bai, Yijun
AU - Wang, Harry H.X.
AU - Yuan, Jinqiu
AU - Zhang, Lin
AU - Yip, Hon Chi
AU - Chiu, Philip Wai Yan
N1 - Funding Information:
DISCLOSURE: All authors disclosed no financial relationships.
Publisher Copyright:
© 2022 American Society for Gastrointestinal Endoscopy
PY - 2022/8
Y1 - 2022/8
N2 - Background and Aims: This systematic review and meta-analysis aims to compare the pooled diagnostic accuracy of the currently available esophageal squamous cell carcinoma (ESCC) screening tests. Methods: A comprehensive literature search of Embase and Medline (up to October 31, 2020) was performed to identify eligible studies. We pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio for ESCC screening tools using a bivariate random-effects model. The summary receiver operating characteristic curves with area under the curve (AUC) were plotted for each screening test. Results: We included 161 studies conducted in 81 research articles involving 32,209 subjects. The pooled sensitivity, specificity, and AUC of the major screening tools were respectively as follows: endoscopy (peroral endoscopy):. 94 (95% confidence interval [CI], 87-.97), 92 (95% CI, 87-.95), and. 97 (95% CI, 96-.99); endoscopy (transnasal endoscopy):. 85 (95% CI, 70-.93), 96 (95% CI, 91-.98), and. 97 (95% CI, 95-.98); microRNA:. 77 (95% CI, 75-.80), 78 (95% CI, 75-.80), and. 85 (95% CI, 81-.87); autoantibody:. 45 (95% CI, 36-.53), 91 (95% CI, 89-.93), and. 84 (95% CI, 81-.87); and cytology:. 82 (95% CI, 60-.93), 97 (95% CI, 88-.99), and. 97 (95% CI, 95-.98). There was high heterogeneity. Conclusions: The diagnostic accuracy seemed to be comparable between cytology and endoscopy, whereas autoantibody and microRNAs bear potential as future noninvasive screening tools for ESCC. To reduce ESCC-related death in high-risk populations, it is important to develop a more accurate and less-invasive screening test.
AB - Background and Aims: This systematic review and meta-analysis aims to compare the pooled diagnostic accuracy of the currently available esophageal squamous cell carcinoma (ESCC) screening tests. Methods: A comprehensive literature search of Embase and Medline (up to October 31, 2020) was performed to identify eligible studies. We pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio for ESCC screening tools using a bivariate random-effects model. The summary receiver operating characteristic curves with area under the curve (AUC) were plotted for each screening test. Results: We included 161 studies conducted in 81 research articles involving 32,209 subjects. The pooled sensitivity, specificity, and AUC of the major screening tools were respectively as follows: endoscopy (peroral endoscopy):. 94 (95% confidence interval [CI], 87-.97), 92 (95% CI, 87-.95), and. 97 (95% CI, 96-.99); endoscopy (transnasal endoscopy):. 85 (95% CI, 70-.93), 96 (95% CI, 91-.98), and. 97 (95% CI, 95-.98); microRNA:. 77 (95% CI, 75-.80), 78 (95% CI, 75-.80), and. 85 (95% CI, 81-.87); autoantibody:. 45 (95% CI, 36-.53), 91 (95% CI, 89-.93), and. 84 (95% CI, 81-.87); and cytology:. 82 (95% CI, 60-.93), 97 (95% CI, 88-.99), and. 97 (95% CI, 95-.98). There was high heterogeneity. Conclusions: The diagnostic accuracy seemed to be comparable between cytology and endoscopy, whereas autoantibody and microRNAs bear potential as future noninvasive screening tools for ESCC. To reduce ESCC-related death in high-risk populations, it is important to develop a more accurate and less-invasive screening test.
UR - https://www.scopus.com/pages/publications/85132812461
U2 - 10.1016/j.gie.2022.04.005
DO - 10.1016/j.gie.2022.04.005
M3 - Review Article
C2 - 35413332
AN - SCOPUS:85132812461
SN - 0016-5107
VL - 96
SP - 197-207.e34
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
IS - 2
ER -