TY - JOUR
T1 - Perforin: structure, function, and role in human immunopathology
AU - Voskoboinik, Ilia
AU - Dunstone, Michelle Anne
AU - Baran, Katherine
AU - Whisstock, James
AU - Trapani, Joseph A
PY - 2010
Y1 - 2010
N2 - The secretory granule-mediated cell death pathway is the key mechanism for elimination of virus-infected and transformed target cells by cytotoxic lymphocytes. The formation of the immunological synapse between an effector and a target cell leads to exocytic trafficking of the secretary granules and the release of their content, which include pro-apoptotic serine proteases, granzymes, and pore-forming perforin into the synapse.......
AB - The secretory granule-mediated cell death pathway is the key mechanism for elimination of virus-infected and transformed target cells by cytotoxic lymphocytes. The formation of the immunological synapse between an effector and a target cell leads to exocytic trafficking of the secretary granules and the release of their content, which include pro-apoptotic serine proteases, granzymes, and pore-forming perforin into the synapse.......
UR - http://www3.interscience.wiley.com/cgi-bin/fulltext/123395688/PDFSTART
U2 - 10.1111/j.0105-2896.2010.00896
DO - 10.1111/j.0105-2896.2010.00896
M3 - Article
SN - 0105-2896
VL - 235
SP - 35
EP - 54
JO - Immunological Reviews
JF - Immunological Reviews
IS - 1
ER -