Perforin: structure, function, and role in human immunopathology

Ilia Voskoboinik, Michelle Anne Dunstone, Katherine Baran, James Whisstock, Joseph A Trapani

Research output: Contribution to journalArticleResearchpeer-review

126 Citations (Scopus)

Abstract

The secretory granule-mediated cell death pathway is the key mechanism for elimination of virus-infected and transformed target cells by cytotoxic lymphocytes. The formation of the immunological synapse between an effector and a target cell leads to exocytic trafficking of the secretary granules and the release of their content, which include pro-apoptotic serine proteases, granzymes, and pore-forming perforin into the synapse.......
Original languageEnglish
Pages (from-to)35 - 54
Number of pages20
JournalImmunological Reviews
Volume235
Issue number1
DOIs
Publication statusPublished - 2010

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