Perforin-dependent cytotoxicity: ‘Kiss of death’ or prolonged embrace with darker consequences?

Joseph A. Trapani, Ilia Voskoboinik, Misty R. Jenkins

Research output: Contribution to journalArticleOtherpeer-review

3 Citations (Scopus)

Abstract

Failure of natural killer (NK) cells or cytotoxic T-lymphocytes (CTL) to kill cognate target cells results in cytokine/chemokine hypersecretion and markedly delayed killer/target cell detachment. With congenital perforin deficiency, fatal cytokine storm results. In cancer cells, where corrupted apoptotic signaling frequently delays apoptosis, we propose that failed death may alter the tumor microenvironment and skew immune infiltrates, even when perforin is delivered normally.

Original languageEnglish
Number of pages2
JournalOncoImmunology
Volume4
Issue number9
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Apoptosis
  • Detachment
  • FHL
  • Granzyme
  • Immunotherapy
  • Inflammation
  • Perforin

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