Perforin-dependent cytotoxicity: ‘Kiss of death’ or prolonged embrace with darker consequences?

Joseph A. Trapani; Ilia Voskoboinik; Misty R. Jenkins

doi:10.1080/2162402X.2015.1036215

Perforin-dependent cytotoxicity: ‘Kiss of death’ or prolonged embrace with darker consequences?

Joseph A. Trapani, Ilia Voskoboinik, Misty R. Jenkins

Research output: Contribution to journal › Article › Other › peer-review

4 Citations (Scopus)

Abstract

Failure of natural killer (NK) cells or cytotoxic T-lymphocytes (CTL) to kill cognate target cells results in cytokine/chemokine hypersecretion and markedly delayed killer/target cell detachment. With congenital perforin deficiency, fatal cytokine storm results. In cancer cells, where corrupted apoptotic signaling frequently delays apoptosis, we propose that failed death may alter the tumor microenvironment and skew immune infiltrates, even when perforin is delivered normally.

Original language	English
Number of pages	2
Journal	OncoImmunology
Volume	4
Issue number	9
DOIs	https://doi.org/10.1080/2162402X.2015.1036215
Publication status	Published - 1 Jan 2015
Externally published	Yes

Keywords

Apoptosis
Detachment
FHL
Granzyme
Immunotherapy
Inflammation
Perforin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/2162402X.2015.1036215

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title = "Perforin-dependent cytotoxicity: {\textquoteleft}Kiss of death{\textquoteright} or prolonged embrace with darker consequences?",

abstract = "Failure of natural killer (NK) cells or cytotoxic T-lymphocytes (CTL) to kill cognate target cells results in cytokine/chemokine hypersecretion and markedly delayed killer/target cell detachment. With congenital perforin deficiency, fatal cytokine storm results. In cancer cells, where corrupted apoptotic signaling frequently delays apoptosis, we propose that failed death may alter the tumor microenvironment and skew immune infiltrates, even when perforin is delivered normally.",

keywords = "Apoptosis, Detachment, FHL, Granzyme, Immunotherapy, Inflammation, Perforin",

author = "Trapani, {Joseph A.} and Ilia Voskoboinik and Jenkins, {Misty R.}",

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doi = "10.1080/2162402X.2015.1036215",

language = "English",

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TY - JOUR

T1 - Perforin-dependent cytotoxicity

T2 - ‘Kiss of death’ or prolonged embrace with darker consequences?

AU - Trapani, Joseph A.

AU - Voskoboinik, Ilia

AU - Jenkins, Misty R.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Failure of natural killer (NK) cells or cytotoxic T-lymphocytes (CTL) to kill cognate target cells results in cytokine/chemokine hypersecretion and markedly delayed killer/target cell detachment. With congenital perforin deficiency, fatal cytokine storm results. In cancer cells, where corrupted apoptotic signaling frequently delays apoptosis, we propose that failed death may alter the tumor microenvironment and skew immune infiltrates, even when perforin is delivered normally.

AB - Failure of natural killer (NK) cells or cytotoxic T-lymphocytes (CTL) to kill cognate target cells results in cytokine/chemokine hypersecretion and markedly delayed killer/target cell detachment. With congenital perforin deficiency, fatal cytokine storm results. In cancer cells, where corrupted apoptotic signaling frequently delays apoptosis, we propose that failed death may alter the tumor microenvironment and skew immune infiltrates, even when perforin is delivered normally.

KW - Apoptosis

KW - Detachment

KW - FHL

KW - Granzyme

KW - Immunotherapy

KW - Inflammation

KW - Perforin

UR - http://www.scopus.com/inward/record.url?scp=84944445840&partnerID=8YFLogxK

U2 - 10.1080/2162402X.2015.1036215

DO - 10.1080/2162402X.2015.1036215

M3 - Article

AN - SCOPUS:84944445840

VL - 4

JO - OncoImmunology

JF - OncoImmunology

SN - 2162-402X

IS - 9

ER -

Perforin-dependent cytotoxicity: ‘Kiss of death’ or prolonged embrace with darker consequences?

Abstract

Keywords

UN SDGs

Access to Document

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