Perforin-A key (shaped) weapon in the immunological arsenal

Research output: Contribution to journalReview ArticleOtherpeer-review

3 Citations (Scopus)

Abstract

Cytotoxic lymphocytes play a key role in immune homeostasis through elimination of virally-infected and transformed target cells. They do this by employing the potent pore-forming protein, perforin, a molecule that permits cytotoxic proteases, such as granzyme B, to enter the target cell cytoplasm. The synergistic activities of perforin and granzymes bring about the destruction of target cells in a process that is now more clearly understood as a result of structural and cellular biology. These data are helping the development of new classes of immunosuppressive molecules for use in treating immune driven disease and in enhancing the success of transplant therapies. This review focuses on structural and biological aspects of perforin function.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume72
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Granzyme
  • MACPF
  • Perforin
  • Pore-forming protein

Cite this

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title = "Perforin-A key (shaped) weapon in the immunological arsenal",
abstract = "Cytotoxic lymphocytes play a key role in immune homeostasis through elimination of virally-infected and transformed target cells. They do this by employing the potent pore-forming protein, perforin, a molecule that permits cytotoxic proteases, such as granzyme B, to enter the target cell cytoplasm. The synergistic activities of perforin and granzymes bring about the destruction of target cells in a process that is now more clearly understood as a result of structural and cellular biology. These data are helping the development of new classes of immunosuppressive molecules for use in treating immune driven disease and in enhancing the success of transplant therapies. This review focuses on structural and biological aspects of perforin function.",
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author = "Spicer, {Bradley A.} and Conroy, {Paul J.} and Law, {Ruby H.P.} and Ilia Voskoboinik and Whisstock, {James C.}",
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Perforin-A key (shaped) weapon in the immunological arsenal. / Spicer, Bradley A.; Conroy, Paul J.; Law, Ruby H.P.; Voskoboinik, Ilia; Whisstock, James C.

In: Seminars in Cell and Developmental Biology, Vol. 72, 12.2017, p. 117-123.

Research output: Contribution to journalReview ArticleOtherpeer-review

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AU - Conroy, Paul J.

AU - Law, Ruby H.P.

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AU - Whisstock, James C.

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AB - Cytotoxic lymphocytes play a key role in immune homeostasis through elimination of virally-infected and transformed target cells. They do this by employing the potent pore-forming protein, perforin, a molecule that permits cytotoxic proteases, such as granzyme B, to enter the target cell cytoplasm. The synergistic activities of perforin and granzymes bring about the destruction of target cells in a process that is now more clearly understood as a result of structural and cellular biology. These data are helping the development of new classes of immunosuppressive molecules for use in treating immune driven disease and in enhancing the success of transplant therapies. This review focuses on structural and biological aspects of perforin function.

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