TY - JOUR
T1 - Peptide therapeutics from venom
T2 - Current status and potential
AU - Pennington, Michael W.
AU - Czerwinski, Andrzej
AU - Norton, Raymond S.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Peptides are recognized as being highly selective, potent and relatively safe as potential therapeutics. Peptides isolated from the venom of different animals satisfy most of these criteria with the possible exception of safety, but when isolated as single compounds and used at appropriate concentrations, venom-derived peptides can become useful drugs. Although the number of venom-derived peptides that have successfully progressed to the clinic is currently limited, the prospects for venom-derived peptides look very optimistic. As proteomic and transcriptomic approaches continue to identify new sequences, the potential of venom-derived peptides to find applications as therapeutics, cosmetics and insecticides grows accordingly.
AB - Peptides are recognized as being highly selective, potent and relatively safe as potential therapeutics. Peptides isolated from the venom of different animals satisfy most of these criteria with the possible exception of safety, but when isolated as single compounds and used at appropriate concentrations, venom-derived peptides can become useful drugs. Although the number of venom-derived peptides that have successfully progressed to the clinic is currently limited, the prospects for venom-derived peptides look very optimistic. As proteomic and transcriptomic approaches continue to identify new sequences, the potential of venom-derived peptides to find applications as therapeutics, cosmetics and insecticides grows accordingly.
UR - http://www.scopus.com/inward/record.url?scp=85030644516&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2017.09.029
DO - 10.1016/j.bmc.2017.09.029
M3 - Article
AN - SCOPUS:85030644516
SN - 0968-0896
VL - 26
SP - 2738
EP - 2758
JO - Bioorganic & Medicinal Chemistry
JF - Bioorganic & Medicinal Chemistry
IS - 10
ER -