PEGylated gold nanoparticles functionalized with ?-cyclodextrin inclusion complexes: Towards metal nanoparticle-polymer-carbohydrate cluster biohybrid materials

Jingquan Liu, Eki Setijadi, Yingkai Liu, Michael Raymond Whittaker, Cyrille Boyer, Thomas Paul Davis

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)


A cholesterol-functional trithiocarbonate reversible additionfragmentation chain transfer (RAFT) agent was synthesized and employed to generate well-defined poly(polyethylene glycol) acrylate with cholesterol chain termini using RAFT polymerization. Subsequently, the polymers were grafted onto the surface of gold nanoparticles using the trithiocarbonate functionality to bind to the gold surface. The cholesterol moieties were then modified via complexation with ?-cyclodextrin. The step-by-step modification of gold nanoparticles was characterized by dynamic light scattering, attenuated total reflection infrared spectroscopy and surface plasmon resonance analysis.
Original languageEnglish
Pages (from-to)1245 - 1250
Number of pages6
JournalAustralian Journal of Chemistry
Issue number8
Publication statusPublished - 2010
Externally publishedYes

Cite this