Pediatric rodent models of traumatic brain injury

Bridgette D. Semple, Jaclyn Carlson, Linda J. Noble-Haeusslein

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

11 Citations (Scopus)

Abstract

Due to a high incidence of traumatic brain injury (TBI) in children and adolescents, age-specific studies are necessary to fully understand the long-term consequences of injuries to the immature brain. Preclinical and translational research can help elucidate the vulnerabilities of the developing brain to insult, and provide model systems to formulate and evaluate potential treatments aimed at minimizing the adverse effects of TBI. Several experimental TBI models have therefore been scaled down from adult rodents for use in juvenile animals. The following chapter discusses these adapted models for pediatric TBI, and the importance of age equivalence across species during model development and interpretation. Many neurodevelopmental processes are ongoing throughout childhood and adolescence, such that neuropathological mechanisms secondary to a brain insult, including oxidative stress, metabolic dysfunction and inflammation, may be influenced by the age at the time of insult. The long-term evaluation of clinically relevant functional outcomes is imperative to better understand the persistence and evolution of behavioral deficits over time after injury to the developing brain. Strategies to modify or protect against the chronic consequences of pediatric TBI, by supporting the trajectory of normal brain development, have the potential to improve quality of life for brain-injured children.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
EditorsFiras Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello
Place of PublicationNew York NY USA
PublisherHumana Press
Pages325-343
Number of pages19
Volume1462
ISBN (Electronic)978-1-4939-3816-2
ISBN (Print)978-1-4939-3814-8
DOIs
Publication statusPublished - 2016
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1462
ISSN (Print)1064-3745

Keywords

  • Behavior
  • Children
  • Juvenile
  • Mice
  • Pediatric
  • Rodents
  • Traumatic brain injury

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