PAX5-expressing ALK-negative anaplastic large cell lymphoma with extensive extranodal and nodal involvement

Doen Ming Ong, Katherine D. Cummins, Alan Pham, George Grigoriadis

Research output: Contribution to journalArticleOtherpeer-review

Abstract

A 55-year-old man with a history of well controlled HIV infection was admitted with acute renal impairment, peripheral oedema, constitutional symptoms, deranged liver function and hypercalcaemia. Core biopsies of a retroperitoneal mass demonstrated anaplastic lymphoma kinase (ALK) negative anaplastic large cell lymphoma (ALCL) with unusual Paired box 5 (PAX5) positivity. The same malignant cells were identifiable on urine cytology. Staging investigations revealed extensive nodal and extranodal disease including ALK negative ALCL involving the kidney and prostate, which has not previously been reported in the published literature.

Original languageEnglish
Article number211159
JournalBMJ Case Reports
Volume2015
DOIs
Publication statusPublished - 17 Jul 2015
Externally publishedYes

Cite this

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title = "PAX5-expressing ALK-negative anaplastic large cell lymphoma with extensive extranodal and nodal involvement",
abstract = "A 55-year-old man with a history of well controlled HIV infection was admitted with acute renal impairment, peripheral oedema, constitutional symptoms, deranged liver function and hypercalcaemia. Core biopsies of a retroperitoneal mass demonstrated anaplastic lymphoma kinase (ALK) negative anaplastic large cell lymphoma (ALCL) with unusual Paired box 5 (PAX5) positivity. The same malignant cells were identifiable on urine cytology. Staging investigations revealed extensive nodal and extranodal disease including ALK negative ALCL involving the kidney and prostate, which has not previously been reported in the published literature.",
author = "Ong, {Doen Ming} and Cummins, {Katherine D.} and Alan Pham and George Grigoriadis",
year = "2015",
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language = "English",
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journal = "BMJ Case Reports",
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PAX5-expressing ALK-negative anaplastic large cell lymphoma with extensive extranodal and nodal involvement. / Ong, Doen Ming; Cummins, Katherine D.; Pham, Alan; Grigoriadis, George.

In: BMJ Case Reports, Vol. 2015, 211159, 17.07.2015.

Research output: Contribution to journalArticleOtherpeer-review

TY - JOUR

T1 - PAX5-expressing ALK-negative anaplastic large cell lymphoma with extensive extranodal and nodal involvement

AU - Ong, Doen Ming

AU - Cummins, Katherine D.

AU - Pham, Alan

AU - Grigoriadis, George

PY - 2015/7/17

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AB - A 55-year-old man with a history of well controlled HIV infection was admitted with acute renal impairment, peripheral oedema, constitutional symptoms, deranged liver function and hypercalcaemia. Core biopsies of a retroperitoneal mass demonstrated anaplastic lymphoma kinase (ALK) negative anaplastic large cell lymphoma (ALCL) with unusual Paired box 5 (PAX5) positivity. The same malignant cells were identifiable on urine cytology. Staging investigations revealed extensive nodal and extranodal disease including ALK negative ALCL involving the kidney and prostate, which has not previously been reported in the published literature.

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