Patterns of hepatitis C virus RNA levels during acute infection: the InC3 study

Behzad Hajarizadeh, Bart Grady, Kimberly A Page, Arthur Y Kim, Barbara H McGovern, Andrea Lynn Cox, Thomas M Rice, Rachel Sacks-Davis, Julie Bruneau, Meghan Morris, Janaki Amin, Janke Schinkel, Tanya Applegate, Lisa Maher, Margaret Elena Hellard, Andrew R Lloyd, Maria Prins, Gregory J Dore, Jason Grebely

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Abstract

Background Understanding the patterns of HCV RNA levels during acute hepatitis C virus (HCV) infection provides insights into immunopathogenesis and is important for vaccine design. This study evaluated patterns of HCV RNA levels and associated factors among individuals with acute infection. Methods Data were from an international collaboration of nine prospective cohorts of acute HCV (InC3 Study). Participants with well-characterized acute HCV infection (detected within three months post-infection and interval between the peak and subsequent HCV RNA levels-=120 days) were categorised by a priori-defined patterns of HCV RNA levels: i) spontaneous clearance, ii) partial viral control with persistence (=1 log IU/mL decline in HCV RNA levels following peak) and iii) viral plateau with persistence (increase or
Original languageEnglish
Article numbere0122232
Number of pages19
JournalPLoS ONE
Volume10
Issue number4
DOIs
Publication statusPublished - 2015

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