Patterned and switchable surfaces for biomolecular manipulation

A. L. Hook, N. H. Voelcker, H. Thissen

Research output: Contribution to journalReview ArticleResearchpeer-review

81 Citations (Scopus)


The interactions of biomolecules and cells with solid interfaces play a pivotal role in a range of biomedical applications and have therefore been studied in great detail. An improved understanding of these interactions results in the ability to manipulate DNA, proteins and other biomolecules, as well as cells, spatially and temporally at surfaces with high precision. This in turn engenders the development of advanced devices, such as biosensors, bioelectronic components, smart biomaterials and microarrays. Spatial control can be achieved by the production of patterned surface chemistries using modern high-resolution patterning technologies based on lithography, microprinting or microfluidics, whilst temporal control is accessible through the application of switchable surface architectures. The combination of these two surface properties offers unprecedented control over the behaviour of biomolecules and cells at the solid-liquid interface. This review discusses the behaviour of biomolecules and cells at solid interfaces and highlights fundamental and applied research exploring patterned and switchable surfaces.

Original languageEnglish
Pages (from-to)2350-2370
Number of pages21
JournalActa Biomaterialia
Issue number7
Publication statusPublished - Sep 2009
Externally publishedYes


  • DNA adsorption
  • Spatial control
  • Surface patterning
  • Switchability
  • Temporal control

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