Abstract
Malignant transformation from normal colonic mucosa to carcinomas may be accelerated by genetic loss or inactivation of genes of the DNA mismatch repair system. The aim of the study was to determine the local incidence and pattern of immunohistochemical expression of mismatch repair proteins namely: hMLH1, hMSH2 and hMSH6 in a series of colorectal carcinomas (CRCs) and correlate this to their clinical and pathological features. Forty-three out of 298 cases of CRCs (14.4 ) showed abnormal staining pattern for mismatch repair proteins with a majority (65.1 ) showing single hMLH1 loss. Tumours with mismatch repair defect (MMR-d) were frequently found at the right side of colon (p
Original language | English |
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Pages (from-to) | 45 - 57 |
Number of pages | 13 |
Journal | The Malaysian Journal of Pathology |
Volume | 35 |
Issue number | 1 |
Publication status | Published - 2013 |