Pattern of hMLH1, hMSH2 and hMSH6 expression and clinical characteristics in a sample of Malaysian colorectal carcinoma cases

Joon Joon Khoo; Andrew Gunn; Suat-Cheng Peh

Pattern of hMLH1, hMSH2 and hMSH6 expression and clinical characteristics in a sample of Malaysian colorectal carcinoma cases

Joon Joon Khoo, Andrew Gunn, Suat-Cheng Peh

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Malignant transformation from normal colonic mucosa to carcinomas may be accelerated by genetic loss or inactivation of genes of the DNA mismatch repair system. The aim of the study was to determine the local incidence and pattern of immunohistochemical expression of mismatch repair proteins namely: hMLH1, hMSH2 and hMSH6 in a series of colorectal carcinomas (CRCs) and correlate this to their clinical and pathological features. Forty-three out of 298 cases of CRCs (14.4 ) showed abnormal staining pattern for mismatch repair proteins with a majority (65.1 ) showing single hMLH1 loss. Tumours with mismatch repair defect (MMR-d) were frequently found at the right side of colon (p

Original language	English
Pages (from-to)	45 - 57
Number of pages	13
Journal	The Malaysian Journal of Pathology
Volume	35
Issue number	1
Publication status	Published - 2013

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title = "Pattern of hMLH1, hMSH2 and hMSH6 expression and clinical characteristics in a sample of Malaysian colorectal carcinoma cases",

abstract = "Malignant transformation from normal colonic mucosa to carcinomas may be accelerated by genetic loss or inactivation of genes of the DNA mismatch repair system. The aim of the study was to determine the local incidence and pattern of immunohistochemical expression of mismatch repair proteins namely: hMLH1, hMSH2 and hMSH6 in a series of colorectal carcinomas (CRCs) and correlate this to their clinical and pathological features. Forty-three out of 298 cases of CRCs (14.4 ) showed abnormal staining pattern for mismatch repair proteins with a majority (65.1 ) showing single hMLH1 loss. Tumours with mismatch repair defect (MMR-d) were frequently found at the right side of colon (p",

author = "Khoo, {Joon Joon} and Andrew Gunn and Suat-Cheng Peh",

year = "2013",

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pages = "45 -- 57",

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T1 - Pattern of hMLH1, hMSH2 and hMSH6 expression and clinical characteristics in a sample of Malaysian colorectal carcinoma cases

AU - Khoo, Joon Joon

AU - Gunn, Andrew

AU - Peh, Suat-Cheng

PY - 2013

Y1 - 2013

N2 - Malignant transformation from normal colonic mucosa to carcinomas may be accelerated by genetic loss or inactivation of genes of the DNA mismatch repair system. The aim of the study was to determine the local incidence and pattern of immunohistochemical expression of mismatch repair proteins namely: hMLH1, hMSH2 and hMSH6 in a series of colorectal carcinomas (CRCs) and correlate this to their clinical and pathological features. Forty-three out of 298 cases of CRCs (14.4 ) showed abnormal staining pattern for mismatch repair proteins with a majority (65.1 ) showing single hMLH1 loss. Tumours with mismatch repair defect (MMR-d) were frequently found at the right side of colon (p

AB - Malignant transformation from normal colonic mucosa to carcinomas may be accelerated by genetic loss or inactivation of genes of the DNA mismatch repair system. The aim of the study was to determine the local incidence and pattern of immunohistochemical expression of mismatch repair proteins namely: hMLH1, hMSH2 and hMSH6 in a series of colorectal carcinomas (CRCs) and correlate this to their clinical and pathological features. Forty-three out of 298 cases of CRCs (14.4 ) showed abnormal staining pattern for mismatch repair proteins with a majority (65.1 ) showing single hMLH1 loss. Tumours with mismatch repair defect (MMR-d) were frequently found at the right side of colon (p

UR - http://www.mjpath.org.my/2013.1/colorectal-carcinoma.pdf

M3 - Article

VL - 35

SP - 45

EP - 57

JO - The Malaysian Journal of Pathology

JF - The Malaysian Journal of Pathology

SN - 0126-8635

IS - 1

ER -