Pattern of hMLH1, hMSH2 and hMSH6 expression and clinical characteristics in a sample of Malaysian colorectal carcinoma cases

Joon Joon Khoo, Andrew Gunn, Suat-Cheng Peh

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    Abstract

    Malignant transformation from normal colonic mucosa to carcinomas may be accelerated by genetic loss or inactivation of genes of the DNA mismatch repair system. The aim of the study was to determine the local incidence and pattern of immunohistochemical expression of mismatch repair proteins namely: hMLH1, hMSH2 and hMSH6 in a series of colorectal carcinomas (CRCs) and correlate this to their clinical and pathological features. Forty-three out of 298 cases of CRCs (14.4 ) showed abnormal staining pattern for mismatch repair proteins with a majority (65.1 ) showing single hMLH1 loss. Tumours with mismatch repair defect (MMR-d) were frequently found at the right side of colon (p
    Original languageEnglish
    Pages (from-to)45 - 57
    Number of pages13
    JournalThe Malaysian Journal of Pathology
    Volume35
    Issue number1
    Publication statusPublished - 2013

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