Patients that benefit from buprenorphine-naloxone on medically assisted treatment for opioid dependence in Malaysia

Philip George Brown, Parameswaran I Ramasamy, Sivakumar Thurairajasingam, Zia Shah

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Introduction: Opioid dependence is recorded as the most common drug of abuse in Malaysia. Currently, the preferred substitution therapy for most Government treatment centres is methadone used as substitution therapy for opioid dependence. There are, however patients who may benefit from being on the combined buprenorphine-naloxone formulation as substitution therapy instead. We discuss six cases of opioid dependence of varied backgrounds that were treated with buprenorphinenaloxone therapy and their outcomes. Discussion: All of the reported patients improved after the induction of buprenorphine- naloxone. Two of the cases highlighted the transfer of patients on methadone to buprenorphine-naloxone due to the adverse effect and interactions of methadone with other medications. During the transfer there were no major adverse reactions noted, and patients were safely able to continue with the maintenance therapy of buprenorphine- naloxone. Conclusion: Buprenorphine-naloxone is a safe and effective drug substitution therapy for opioid dependence. It has fewer interactions with other medications, and has similar efficacy to methadone. Being a partial agonist, it has a less sedating effect making patients more functional.
Original languageEnglish
Pages (from-to)251 - 255
Number of pages5
JournalMedical Journal of Malaysia
Volume70
Issue number4
Publication statusPublished - 2015

Cite this

Brown, Philip George ; Ramasamy, Parameswaran I ; Thurairajasingam, Sivakumar ; Shah, Zia. / Patients that benefit from buprenorphine-naloxone on medically assisted treatment for opioid dependence in Malaysia. In: Medical Journal of Malaysia. 2015 ; Vol. 70, No. 4. pp. 251 - 255.
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title = "Patients that benefit from buprenorphine-naloxone on medically assisted treatment for opioid dependence in Malaysia",
abstract = "Introduction: Opioid dependence is recorded as the most common drug of abuse in Malaysia. Currently, the preferred substitution therapy for most Government treatment centres is methadone used as substitution therapy for opioid dependence. There are, however patients who may benefit from being on the combined buprenorphine-naloxone formulation as substitution therapy instead. We discuss six cases of opioid dependence of varied backgrounds that were treated with buprenorphinenaloxone therapy and their outcomes. Discussion: All of the reported patients improved after the induction of buprenorphine- naloxone. Two of the cases highlighted the transfer of patients on methadone to buprenorphine-naloxone due to the adverse effect and interactions of methadone with other medications. During the transfer there were no major adverse reactions noted, and patients were safely able to continue with the maintenance therapy of buprenorphine- naloxone. Conclusion: Buprenorphine-naloxone is a safe and effective drug substitution therapy for opioid dependence. It has fewer interactions with other medications, and has similar efficacy to methadone. Being a partial agonist, it has a less sedating effect making patients more functional.",
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Brown, PG, Ramasamy, PI, Thurairajasingam, S & Shah, Z 2015, 'Patients that benefit from buprenorphine-naloxone on medically assisted treatment for opioid dependence in Malaysia' Medical Journal of Malaysia, vol. 70, no. 4, pp. 251 - 255.

Patients that benefit from buprenorphine-naloxone on medically assisted treatment for opioid dependence in Malaysia. / Brown, Philip George; Ramasamy, Parameswaran I; Thurairajasingam, Sivakumar; Shah, Zia.

In: Medical Journal of Malaysia, Vol. 70, No. 4, 2015, p. 251 - 255.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Ramasamy, Parameswaran I

AU - Thurairajasingam, Sivakumar

AU - Shah, Zia

PY - 2015

Y1 - 2015

N2 - Introduction: Opioid dependence is recorded as the most common drug of abuse in Malaysia. Currently, the preferred substitution therapy for most Government treatment centres is methadone used as substitution therapy for opioid dependence. There are, however patients who may benefit from being on the combined buprenorphine-naloxone formulation as substitution therapy instead. We discuss six cases of opioid dependence of varied backgrounds that were treated with buprenorphinenaloxone therapy and their outcomes. Discussion: All of the reported patients improved after the induction of buprenorphine- naloxone. Two of the cases highlighted the transfer of patients on methadone to buprenorphine-naloxone due to the adverse effect and interactions of methadone with other medications. During the transfer there were no major adverse reactions noted, and patients were safely able to continue with the maintenance therapy of buprenorphine- naloxone. Conclusion: Buprenorphine-naloxone is a safe and effective drug substitution therapy for opioid dependence. It has fewer interactions with other medications, and has similar efficacy to methadone. Being a partial agonist, it has a less sedating effect making patients more functional.

AB - Introduction: Opioid dependence is recorded as the most common drug of abuse in Malaysia. Currently, the preferred substitution therapy for most Government treatment centres is methadone used as substitution therapy for opioid dependence. There are, however patients who may benefit from being on the combined buprenorphine-naloxone formulation as substitution therapy instead. We discuss six cases of opioid dependence of varied backgrounds that were treated with buprenorphinenaloxone therapy and their outcomes. Discussion: All of the reported patients improved after the induction of buprenorphine- naloxone. Two of the cases highlighted the transfer of patients on methadone to buprenorphine-naloxone due to the adverse effect and interactions of methadone with other medications. During the transfer there were no major adverse reactions noted, and patients were safely able to continue with the maintenance therapy of buprenorphine- naloxone. Conclusion: Buprenorphine-naloxone is a safe and effective drug substitution therapy for opioid dependence. It has fewer interactions with other medications, and has similar efficacy to methadone. Being a partial agonist, it has a less sedating effect making patients more functional.

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