Patient preferences to value health outcomes in rheumatology clinical trials: Report from the OMERACT special interest group

Megan Thomas, Liana Fraenkel, Annelies Boonen, Nick Bansback, Rachelle Buchbinder, Deborah Marshall, Laurie Proulx, Marieke Voshaar, Pamela Richards, Dawn P. Richards, Mickael Hiligsmann, Francis Guillemin, Beverly Shea, Peter Tugwell, Glen Hazlewood

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)


Objective: To inform a research plan for future studies by obtaining stakeholder input on the application of preference-based methods to clinical trial design. Methods: We conducted a virtual OMERACT session to encourage stakeholder engagement. We developed materials for the session to facilitate discussion based on identified case examples and feedback sessions. Results: Participants prioritized incorporating patient preferences in all aspects of trial design with an emphasis on outcome selection. Participants highlighted the need for careful consideration around preference heterogeneity and equity factors. Conclusion: Including patient preferences in trial design was considered a priority requiring further exploration to develop comprehensive guidance.

Original languageEnglish
Pages (from-to)919-924
Number of pages6
JournalSeminars in Arthritis and Rheumatism
Issue number4
Publication statusPublished - Aug 2021


  • Clinical trials
  • Patient preferences
  • Preference-based methods
  • Rheumatology
  • Trade-offs

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