Patient-Derived Xenograft Models for Ovarian Cancer

Trang Minh Tran, Gwo Yaw Ho, Simon Chu

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Patient-derived xenograft (PDX) models play a crucial role for in vivo research. They maintain the original molecular characteristics of the human tumor and provide a more accurate tumor microenvironment, which cannot be replicated by in vitro models. This chapter describes four different transplantation methods, namely, intra-bursal, intrarenal capsule, intraperitoneal, and subcutaneous, to develop PDX models for ovarian cancer research.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
EditorsMohamed I. Saad
Place of PublicationNew York NY USA
PublisherHumana Press
Chapter13
Pages187-196
Number of pages10
ISBN (Electronic)9781071638583
ISBN (Print)9781071638576
DOIs
Publication statusPublished - 2024

Publication series

NameMethods in Molecular Biology
Volume2806
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Intra-bursal
  • Intraperitoneal
  • Intrarenal capsule
  • Ovarian cancer
  • Patient-derived xenograft (PDX)
  • Subcutaneous

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