Patient-Derived Induced Pluripotent Stem Cells to Target Kidney Disease

Felicity J Barnes, Sharon D Ricardo

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

The reprogramming of adult cells to generate induced pluripotent stem (iPS) cells has advanced the study of disease modeling and is potentially of use as autologous cell replacement therapy. This chapter discusses opportunities for the differentiation of iPS cells into kidney lineages and the challenges of reprogramming for in vitro disease modeling and therapeutic intervention. Specifically, it will address the use of patient-derived iPS cells as tools for understanding how mutations cause disease, for nephrotoxicity assays and drug discovery, and for disease-modifying bioassays. Ultimately, a more detailed understanding of cell reprogramming and directed differentiation must be developed before iPS technology can be used as a treatment for kidney disease. Despite limits to our understanding of iPS differentiation and obstacles to iPS therapeutic applications, cellular reprogramming may help elucidate mechanisms of cell dedifferentiation and development, providing fundamental information on endogenous cell replacement mechanisms after injury.

Original languageEnglish
Title of host publicationKidney Development, Disease, Repair and Regeneration
EditorsMelissa H. Little
Place of PublicationLondon UK
PublisherAcademia Press
Chapter36
Pages491-505
Number of pages15
Edition1st
ISBN (Electronic)9780128004388
ISBN (Print)9780128001028
DOIs
Publication statusPublished - 2016

Keywords

  • Cell therapy
  • Disease modeling
  • Induced pluripotent stem cells
  • Kidney disease

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