Abstract
| Original language | English |
|---|---|
| Title of host publication | Kidney Development, Disease, Repair and Regeneration |
| Editors | Melissa H. Little |
| Place of Publication | London UK |
| Publisher | Academia Press |
| Pages | 491-505 |
| Number of pages | 15 |
| Edition | 1st |
| ISBN (Print) | 978-0-12-800102-8 |
| DOIs | |
| Publication status | Published - 2016 |
Cite this
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Patient-Derived Induced Pluripotent Stem Cells to Target Kidney Disease. / Barnes, Felicity J; Ricardo, Sharon D.
Kidney Development, Disease, Repair and Regeneration. ed. / Melissa H. Little. 1st. ed. London UK : Academia Press, 2016. p. 491-505.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
TY - CHAP
T1 - Patient-Derived Induced Pluripotent Stem Cells to Target Kidney Disease
AU - Barnes, Felicity J
AU - Ricardo, Sharon D
PY - 2016
Y1 - 2016
N2 - Induced pluripotent stem cells are produced by dedifferentiation or genetic reprogramming of adult cells. This dedifferentiation of somatic cells is traditionally induced by overexpression of four transcription factor genes, Oct3/4, Sox2, Klf4, and c-Myc, which causes them to return to a highly proliferative and pluripotent state, comparable to that of embryonic stem (ES) cells [1,2]. In 2006, Takahashi and Yamanaka described the generation of iPS cells using retroviral-mediated transduction of embryonic and adult mouse tail-tip fibroblasts [1]. In 2007, this protocol was successfully used to reprogram human dermal fibroblasts [2].
AB - Induced pluripotent stem cells are produced by dedifferentiation or genetic reprogramming of adult cells. This dedifferentiation of somatic cells is traditionally induced by overexpression of four transcription factor genes, Oct3/4, Sox2, Klf4, and c-Myc, which causes them to return to a highly proliferative and pluripotent state, comparable to that of embryonic stem (ES) cells [1,2]. In 2006, Takahashi and Yamanaka described the generation of iPS cells using retroviral-mediated transduction of embryonic and adult mouse tail-tip fibroblasts [1]. In 2007, this protocol was successfully used to reprogram human dermal fibroblasts [2].
UR - http://www.sciencedirect.com/science/book/9780128001028#ancs04
U2 - 10.1016/B978-0-12-800102-8.00036-9
DO - 10.1016/B978-0-12-800102-8.00036-9
M3 - Chapter (Book)
SN - 978-0-12-800102-8
SP - 491
EP - 505
BT - Kidney Development, Disease, Repair and Regeneration
A2 - Little, Melissa H.
PB - Academia Press
CY - London UK
ER -