Patient-Derived Induced Pluripotent Stem Cells to Target Kidney Disease

Felicity J Barnes, Sharon D Ricardo

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Induced pluripotent stem cells are produced by dedifferentiation or genetic reprogramming of adult cells. This dedifferentiation of somatic cells is traditionally induced by overexpression of four transcription factor genes, Oct3/4, Sox2, Klf4, and c-Myc, which causes them to return to a highly proliferative and pluripotent state, comparable to that of embryonic stem (ES) cells [1,2]. In 2006, Takahashi and Yamanaka described the generation of iPS cells using retroviral-mediated transduction of embryonic and adult mouse tail-tip fibroblasts [1]. In 2007, this protocol was successfully used to reprogram human dermal fibroblasts [2].
Original languageEnglish
Title of host publicationKidney Development, Disease, Repair and Regeneration
EditorsMelissa H. Little
Place of PublicationLondon UK
PublisherAcademia Press
Pages491-505
Number of pages15
Edition1st
ISBN (Print)978-0-12-800102-8
DOIs
Publication statusPublished - 2016

Cite this

Barnes, F. J., & Ricardo, S. D. (2016). Patient-Derived Induced Pluripotent Stem Cells to Target Kidney Disease. In M. H. Little (Ed.), Kidney Development, Disease, Repair and Regeneration (1st ed., pp. 491-505). London UK: Academia Press. https://doi.org/10.1016/B978-0-12-800102-8.00036-9
Barnes, Felicity J ; Ricardo, Sharon D. / Patient-Derived Induced Pluripotent Stem Cells to Target Kidney Disease. Kidney Development, Disease, Repair and Regeneration. editor / Melissa H. Little. 1st. ed. London UK : Academia Press, 2016. pp. 491-505
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Barnes, FJ & Ricardo, SD 2016, Patient-Derived Induced Pluripotent Stem Cells to Target Kidney Disease. in MH Little (ed.), Kidney Development, Disease, Repair and Regeneration. 1st edn, Academia Press, London UK, pp. 491-505. https://doi.org/10.1016/B978-0-12-800102-8.00036-9

Patient-Derived Induced Pluripotent Stem Cells to Target Kidney Disease. / Barnes, Felicity J; Ricardo, Sharon D.

Kidney Development, Disease, Repair and Regeneration. ed. / Melissa H. Little. 1st. ed. London UK : Academia Press, 2016. p. 491-505.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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Barnes FJ, Ricardo SD. Patient-Derived Induced Pluripotent Stem Cells to Target Kidney Disease. In Little MH, editor, Kidney Development, Disease, Repair and Regeneration. 1st ed. London UK: Academia Press. 2016. p. 491-505 https://doi.org/10.1016/B978-0-12-800102-8.00036-9