Pathophysiology of septic acute kidney injury: what do we really know?

Li Wan, Sean M Bagshaw, Christoph Langenberg, Takao Saotome, Clive N May, Rinaldo Bellomo

Research output: Contribution to journalArticleResearchpeer-review

258 Citations (Scopus)


Septic acute kidney injury accounts for close to 50 of all cases of acute kidney injury in the intensive care unit and, in its various forms, affects between 15 and 20 of intensive care unit patients. However, there is little we really know about its pathophysiology. Although hemodynamic factors might play a role in the loss of glomerular filtration rate, they may not act through the induction of renal ischemia. Septic acute renal failure may, at least in patients with a hyperdynamic circulation, represent a unique form of acute renal failure: hyperemic acute renal failure. Measurements of renal blood flow in septic humans are now needed to resolve this pivotal pathophysiological question. Whatever may happen to renal blood flow during septic acute kidney injury in humans, the evidence available suggests that urinalysis fails to provide useful diagnostic or prognostic information in this setting. In addition, nonhemodynamic mechanisms of cell injury are likely to be at work. These mechanisms are likely due to a combination of immunologic, toxic, and inflammatory factors that may affect the microvasculature and the tubular cells. Among these mechanisms, apoptosis may turn out to be important. It is possible that, as evidence accumulates, the paradigms currently used to explain acute renal failure in sepsis will shift from ischemia and vasoconstriction to hyperemia and vasodilation and from acute tubular necrosis to acute tubular apoptosis or simply tubular cell dysfunction or exfoliation. If this were to happen, our therapeutic approaches would also be profoundly altered.
Original languageEnglish
Pages (from-to)S198 - S203
Number of pages6
JournalCritical Care
Issue number4
Publication statusPublished - 2008
Externally publishedYes

Cite this

Wan, L., Bagshaw, S. M., Langenberg, C., Saotome, T., May, C. N., & Bellomo, R. (2008). Pathophysiology of septic acute kidney injury: what do we really know? Critical Care, 36(4), S198 - S203.