Pathophysiology of Atrial Fibrillation and Heart Failure: Dangerous Interactions

Hariharan Sugumar, Shane Nanayakkara, Sandeep Prabhu, Aleksandr Voskoboinik, David M. Kaye, Liang Han Ling, Peter M. Kistler

Research output: Contribution to journalReview ArticleOtherpeer-review

31 Citations (Scopus)


Atrial fibrillation and heart failure (HF) frequently coexist and are associated with a significant increase in morbidity and mortality. Despite the shared common risk factors atrial fibrillation and HF subtypes exacerbate each other. This review provides an overview of the pathophysiologic relationship between atrial fibrillation and the two most common types of heart failure syndromes: HF with reduced ejection fraction and HF with preserved ejection fraction.

Original languageEnglish
Pages (from-to)131-138
Number of pages8
JournalCardiology Clinics
Issue number2
Publication statusPublished - May 2019


  • Atrial fibrillation
  • Cardiomyopathy
  • Diastolic dysfunction
  • Heart failure
  • HFpEF
  • HFrEF
  • Pathophysiology
  • Tachycardiomyopathy

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