Pathophysiology and treatment of stroke: Present status and future perspectives

Diji Kuriakose, Zhicheng Xiao

Research output: Contribution to journalReview ArticleOtherpeer-review

492 Citations (Scopus)


Stroke is the second leading cause of death and a major contributor to disability worldwide. The prevalence of stroke is highest in developing countries, with ischemic stroke being the most common type. Considerable progress has been made in our understanding of the pathophysiology of stroke and the underlying mechanisms leading to ischemic insult. Stroke therapy primarily focuses on restoring blood flow to the brain and treating stroke-induced neurological damage. Lack of success in recent clinical trials has led to significant refinement of animal models, focus-driven study design and use of new technologies in stroke research. Simultaneously, despite progress in stroke management, post-stroke care exerts a substantial impact on families, the healthcare system and the economy. Improvements in pre-clinical and clinical care are likely to underpin successful stroke treatment, recovery, rehabilitation and prevention. In this review, we focus on the pathophysiology of stroke, major advances in the identification of therapeutic targets and recent trends in stroke research.

Original languageEnglish
Article number7609
Pages (from-to)1-24
Number of pages24
JournalInternational Journal of Molecular Sciences
Issue number20
Publication statusPublished - 2 Oct 2020


  • Neurological deficit
  • Pathophysiology
  • Recovery
  • Rehabilitation
  • Stroke
  • Treatment

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