Pathological interactions with the timing of birth and uterine activation

Roger Smith, Dirk F Van Helden, Jonathon J Hirst, Tamas Zakar, Mark Read, Eng-Cheng Chan, Hannah K Palliser, Dimitris Grammatopoulos, Richard Nicholson, Helena Cecilia Parkington

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15 Citations (Scopus)


The physiological processes that regulate the onset of parturition and birth are slowly being elucidated, and the points at which pathology can intervene are becoming more apparent. The data support the view that multiple pathways lead to myometrial activation. The clinical corollary is that combinations of tocolytics that operate via different mechanisms may be more effective than single agents. It may also be necessary to divide preterm labour into groups based on underlying mechanisms and to tailor therapy accordingly.
Original languageEnglish
Pages (from-to)430 - 437
Number of pages8
JournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
Issue number6
Publication statusPublished - 2007

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