Pathogenesis of crohn's disease

Ray Boyapati, Jack Satsangi, Gwo Tzer Ho

Research output: Contribution to journalReview ArticleResearchpeer-review

76 Citations (Scopus)


Significant progress in our understanding of Crohn's disease (CD), an archetypal common, complex disease, has now been achieved. Our ability to interrogate the deep complexities of the biological processes involved in maintaining gut mucosal homeostasis is a major over-riding factor underpinning this rapid progress. Key studies now offer many novel and expansive insights into the interacting roles of genetic susceptibility, immune function, and the gut microbiota in CD. Here, we provide overviews of these recent advances and new mechanistic themes, and address the challenges and prospects for translation from concept to clinic.

Original languageEnglish
Article number44
Number of pages18
JournalF1000 Prime Reports
Publication statusPublished - 2 Apr 2015
Externally publishedYes

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