Patched 1 conditional null allele in mice

Tammy Ellis, Ian Macleod Smyth, Emily Riley, Scott Graham, Kate Elliot, Monica Narang, Graham F Kay, Carol Wicking, Brandon Wainwright

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Abstract

Summary: The patched gene (Ptc) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues. In addition, Ptc and a number of other pathway members are mutated in some common human cancers. Patched is the receptor for the hedgehog ligand and in the mouse ablation of the Ptc gene leads to developmental defects and an embryonic lethal phenotype. Here we describe a conditional Ptc allele in mice which will have utility for the temporospatial ablation of Ptc function.
Original languageEnglish
Pages (from-to)158 - 161
Number of pages4
Journalgenesis: The Journal of Genetics and Development
Volume36
Issue number3
Publication statusPublished - 2003

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