Colloidal drug delivery systems have been providing alternative formulation approaches for problematic drug candidates, and improved delivery for existing compounds for decades. Colloidal systems for drug delivery have all evolved down from a similar pathway, almost irrespective of the delivery systems, form concpetion, to the use of safer excipients, PEGylation for passive targeting and attachment of ligands for active targeting. The recent emergence of truly biologically interactive systems represents the latest step forward in colloidal delivery systems. Int his article, the maturation pathway and recent advances for the major classes of colloidal delivery systems are reviewed, and the paper poses the quaetions of whether the nanotechnology boom will create a revoltuion in colloidal delivery, or just the next natural stage in evolution.
|Pages (from-to)||69 - 85|
|Number of pages||17|
|Journal||Expert Opinion on Drug Delivery|
|Publication status||Published - 2008|